Universität zu Köln

Miller, K., Albers, P., Eichenauer, R., Geiges, G., Grimm, M-O., Koenig, F., Mickisch, G., Pfister, D., Schwentner, C., Suttmann, H. and Zastrow, S. (2016). Metastatic castration-resistant prostate cancer. Clinical data, new treatment options and therapy monitoring. Urologe, 55 (9). S. 1206 - 1213. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

Therapies currently available in Germany for metastatic castration-resistant prostate cancer (mCRPC) include docetaxel, cabazitaxel, abiraterone acetate, enzalutamide and radium-223, all of which offer a potential survival benefit that adds up in their sequential application to a significant overall survival benefit. However, the optimal sequencing of these agents is still unclear. In the absence of evidence, treatment selection is based on the particular situation and on comorbid conditions of each individual patient. Furthermore, predictive markers to facilitate the selection of patients for a specific therapy or sequence of therapies remain an unmet need. However, with the recently discovered androgen receptor splice variant V7, which mediates (cross)resistance to or between abiraterone and enzalutamide, the first such marker has been identified. It is critical to monitor the response to treatments at prespecified intervals in order to optimize treatment sequencing so that the patient does not miss a valuable therapeutic window to receive alternative treatment that may prolong his life along with good symptom control and preservation of quality of life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Miller, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Albers, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geiges, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimm, M-O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mickisch, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfister, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwentner, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Suttmann, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zastrow, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-266066
DOI:	10.1007/s00120-016-0176-4
Journal or Publication Title:	Urologe
Volume:	55
Number:	9
Page Range:	S. 1206 - 1213
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TESTOSTERONE; ABIRATERONE Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26606