Universität zu Köln

Stewardson, A. J., Allignol, A., Beyersmann, J., Graves, N., Schumacher, M., Meyer, R., Tacconelli, E., De Angelis, G., Farina, C., Pezzoli, F., Bertrand, X., Gbaguidi-Haore, H., Edgeworth, J., Tosas, O., Martinez, J. A., Ayala-Blanco, M. P., Pan, A., Zoncada, A., Marwick, C. A., Nathwani, D., Seifert, H., Hos, N., Hagel, S., Pletz, M. and Harbarth, S. (2016). The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study. Eurosurveillance, 21 (33). S. 5 - 17. STOCKHOLM: EUR CENTRE DIS PREVENTION & CONTROL. ISSN 1560-7917

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Abstract

We performed a multicentre retrospective cohort study including 606,649 acute inpatient episodes at 10 European hospitals in 2010 and 2011 to estimate the impact of antimicrobial resistance on hospital mortality, excess length of stay (LOS) and cost. Bloodstream infections (BSI) caused by third-generation cephalosporin- resistant Enterobacteriaceae (3GCRE), meticillin-susceptible (MSSA) and - resistant Staphylococcus aureus (MRSA) increased the daily risk of hospital death (adjusted hazard ratio (HR) = 1.80; 95% confidence interval (CI): 1.34-2.42, HR = 1.81; 95% CI: 1.49-2.20 and HR = 2.42; 95% CI: 1.66-3.51, respectively) and prolonged LOS (9.3 days; 95% CI: 9.2-9.4, 11.5 days; 95% CI: 11.5-11.6 and 13.3 days; 95% CI: 13.2-13.4, respectively). BSI with third-generation cephalosporin-susceptible Enterobacteriaceae (3GCSE) significantly increased LOS (5.9 days; 95% CI: 5.8-5.9) but not hazard of death (1.16; 95% CI: 0.98-1.36). 3GCRE significantly increased the hazard of death (1.63; 95% CI: 1.13-2.35), excess LOS (4.9 days; 95% CI: 1.1-8.7) and cost compared with susceptible strains, whereas meticillin resistance did not. The annual cost of 3GCRE BSI was higher than of MRSA BSI. While BSI with S. aureus had greater impact on mortality, excess LOS and cost than Enterobacteriaceae per infection, the impact of antimicrobial resistance was greater for Enterobacteriaceae.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stewardson, A. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allignol, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyersmann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graves, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacconelli, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED De Angelis, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Farina, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pezzoli, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertrand, X. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gbaguidi-Haore, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Edgeworth, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tosas, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez, J. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ayala-Blanco, M. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pan, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoncada, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marwick, C. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nathwani, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pletz, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Harbarth, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-266468
DOI:	10.2807/1560-7917.ES.2016.21.33.30319
Journal or Publication Title:	Eurosurveillance
Volume:	21
Number:	33
Page Range:	S. 5 - 17
Date:	2016
Publisher:	EUR CENTRE DIS PREVENTION & CONTROL
Place of Publication:	STOCKHOLM
ISSN:	1560-7917
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LACTAMASE-PRODUCING ENTEROBACTERIACEAE; ANTIBIOTIC-RESISTANCE; ADMINISTRATIVE DATA; MODELS; TRENDS; STAY Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26646