Budjan, Johannes, Sauter, Elke A., Morelli, John N., Nolden, Marco ORCID: 0000-0001-9629-0564, Fetzer, Andreas, Pilz, Lothar, Reichert, Miriam, Brandt, Theresa, Hansmann, Jan, Haneder, Stefan, Rathmann, Nils, Diehl, Steffen J., Meinzer, Hans-Peter, Schoenberg, Stefan O. and Attenberger, Ulrike I. (2016). Semi-automatic Volumetric Measurement of Treatment Response in Hepatocellular Carcinoma After Trans-arterial Chemoembolization. Anticancer Res., 36 (8). S. 4353 - 4359. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Aim: To perform a quantitative, volumetric analysis of therapeutic effects of trans-arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. Patients and Methods: Entire tumor volume and a subset of hypervascular tumor portions were analyzed pre- and post-TACE in magnetic resonance imaging datasets of 22 HCC patients using a semi-automated segmentation and evaluation tool from the Medical Imaging Interaction Toolkit. Results were compared to mRECIST measurements and inter-reader variability was assessed. Results: Mean total tumor volume increased statistical significantly after TACE (84.6 ml pre-vs. 97.1 ml post-TACE, p=0.03) while hypervascular tumor volume decreased from 9.1 ml pre- to 3.7 ml post-TACE (p=0.0001). Likewise, mRECIST diameters decreased significantly after therapy (44.2 vs. 15.4 mm). In the inter-reader assessment, overlap errors were 12.3-17.7% for entire and 36.3-64.2% for the enhancing tumor volume. Conclusion: Quantification of therapeutic changes after TACE therapy is feasible using a semi-automated segmentation and evaluation tool. Following TACE, hypervascular tumor volume decreases significantly.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Budjan, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sauter, Elke A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morelli, John N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nolden, MarcoUNSPECIFIEDorcid.org/0000-0001-9629-0564UNSPECIFIED
Fetzer, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilz, LotharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichert, MiriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandt, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansmann, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haneder, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rathmann, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diehl, Steffen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meinzer, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenberg, Stefan O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attenberger, Ulrike I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-267475
Journal or Publication Title: Anticancer Res.
Volume: 36
Number: 8
Page Range: S. 4353 - 4359
Date: 2016
Publisher: INT INST ANTICANCER RESEARCH
Place of Publication: ATHENS
ISSN: 1791-7530
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
IMAGING INTERACTION TOOLKIT; TRANSARTERIAL CHEMOEMBOLIZATION; LIVER SEGMENTATION; TUMOR RESPONSE; SOLID TUMORS; LUNG-CANCER; METASTASES; SURVIVAL; CRITERIA; RECISTMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26747

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