Universität zu Köln

Behrens, Juliane, Solga, Roxana, Ziemann, Anja, Rastetter, Raphael H., Berwanger, Carolin, Herrmann, Harald, Noegel, Angelika A. and Clemen, Christoph S. (2016). Coronin 1C-free primary mouse fibroblasts exhibit robust rearrangements in the orientation of actin filaments, microtubules and intermediate filaments. Eur. J. Cell Biol., 95 (8). S. 239 - 252. JENA: ELSEVIER GMBH, URBAN & FISCHER VERLAG. ISSN 1618-1298

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Abstract

Coronin 1C is an established modulator of actin cytoskeleton dynamics. It has been shown to be involved in protrusion formation, cell migration and invasion. Here, we report the generation of primary fibroblasts from coronin 1C knock-out mice in order to investigate the impact of the loss of coronin 1C on cellular structural organisation. We demonstrate that the lack of coronin 1C not only affects the actin system, but also the microtubule and the vimentin intermediate filament networks. In particular, we show that the knock-out cells exhibit a reduced proliferation rate, impaired cell migration and protrusion formation as well as an aberrant subcellular localisation and function of mitochondria. Moreover, we demonstrate that coronin 1C specifically interacts with the non-alpha-helical amino-terminal domain (head) of vimentin. Our data suggest that coronin 1C acts as a cytoskeletal integrator of actin filaments, microtubules and intermediate filaments. (C) 2016 The Authors. Published by Elsevier GmbH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behrens, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Solga, Roxana UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziemann, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Rastetter, Raphael H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berwanger, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Noegel, Angelika A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clemen, Christoph S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267705
DOI:	10.1016/j.ejcb.2016.04.004
Journal or Publication Title:	Eur. J. Cell Biol.
Volume:	95
Number:	8
Page Range:	S. 239 - 252
Date:	2016
Publisher:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Place of Publication:	JENA
ISSN:	1618-1298
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INHIBITS CELL-MIGRATION; F-ACTIN; GLIOBLASTOMA CELLS; BINDING-PROTEIN; EXPRESSION; MITOCHONDRIA; ASSOCIATION; MEMBRANE; VIMENTIN; PLECTIN Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26770