Universität zu Köln

Fuks, Kateryna B., Weinmayr, Gudrun, Hennig, Frauke ORCID: 0000-0002-8769-7976, Tzivian, Lilian ORCID: 0000-0001-6253-9130, Moebus, Susanne, Jakobs, Hermann, Memmesheimer, Michael, Kaelsch, Hagen, Andrich, Silke, Nonnemacher, Michael, Erbel, Raimund, Joeckel, Karl-Heinz and Hoffmann, Barbara (2016). Association of long-term exposure to local industry- and traffic-specific particulate matter with arterial blood pressure and incident hypertension. Int. J. Hyg. Environ. Health., 219 (6). S. 527 - 536. MUNICH: ELSEVIER GMBH. ISSN 1618-131X

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Abstract

Background: Long-term exposure to fine particulate matter (PM2.5) may lead to increased blood pressure (BP). The role of industry- and traffic-specific PM2.5 remains unclear. Objective: We investigated the associations of residential long-term source-specific PM2.5 exposure with arterial BP and incident hypertension in the population-based Heinz Nixdorf Recall cohort study. Methods: We defined hypertension as systolic BP >= 140 mmHg, or diastolic BP >= 90 mmHg, or current use of BP lowering medication. Long-term concentrations of PM2.5 from all local sources (PM2.5ALL), local industry (PM2.5IND) and traffic (PM2.5TRA) were modeled with a dispersion and chemistry transport model (EURAD-CTM) with a 1 km(2) resolution. We performed a cross-sectional analysis with BP and prevalent hypertension at baseline, using linear and logistic regression, respectively, and a longitudinal analysis with incident hypertension at 5-year follow-up, using Poisson regression with robust variance estimation. We adjusted for age, sex, body mass index, lifestyle, education, and major road proximity. Change in BP (mmHg), odds ratio (OR) and relative risk (RR) for hypertension were calculated per 1 mu g/m(3) of exposure concentration. Results: PM2.5ALL was highly correlated with PM25IND. (Spearman's rho = 0.92) and moderately with PM2.5TRA (rho = 0.42). In adjusted cross-sectional analysis with 4539 participants, we found positive associations of PM2.5ALL with systolic (0.42 [95%-CI: 0.03, 0.801) and diastolic (0.25 [0.04, 0.461] BP. Higher, but less precise estimates were found for PM2.5IND (systolic: 0.55 [-0.05, 1.14]; diastolic: 0.35 [0.03, 0.671) and PM2.5TRA (systolic: 0.88 [-1.55, 3.31]; diastolic: 0.41 [-0.91, 1.731). We found crude positive association of PM2.5TRA with prevalence (OR 1.41 [1.10, 1.80]) and incidence of hypertension (RR 1.38 [1.03,1.85]), attenuating after adjustment (OR 1.19 [0.90, 1.58] and RR 1.28 [0.94, 1.72]). We found no association of PM2.5ALL and PM2.5IND with hypertension. Conclusions: Long-term exposures to all-source and industry-specific PM2.5 were positively related to BP. We could not separate the effects of industry-specific PM2.5 from all-source PM2.5. Estimates with traffic-specific PM2.5 were generally higher but inconclusive. (C) 2016 Published by Elsevier GmbH.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fuks, Kateryna B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinmayr, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Frauke UNSPECIFIED orcid.org/0000-0002-8769-7976 UNSPECIFIED Tzivian, Lilian UNSPECIFIED orcid.org/0000-0001-6253-9130 UNSPECIFIED Moebus, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakobs, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Memmesheimer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaelsch, Hagen UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrich, Silke UNSPECIFIED UNSPECIFIED UNSPECIFIED Nonnemacher, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Erbel, Raimund UNSPECIFIED UNSPECIFIED UNSPECIFIED Joeckel, Karl-Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-267890
DOI:	10.1016/j.ijheh.2016.05.008
Journal or Publication Title:	Int. J. Hyg. Environ. Health.
Volume:	219
Number:	6
Page Range:	S. 527 - 536
Date:	2016
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	1618-131X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELF-REPORTED HYPERTENSION; AIR-POLLUTION EXPOSURE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; HEART-RATE; NOISE; ATHEROSCLEROSIS; PREVENTION Multiple languages Public, Environmental & Occupational Health; Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26789