Universität zu Köln

Buerkle, Carolin and Borchmann, Peter (2016). Diagnosis and treatment of Hodgkin lymphoma. Onkologe, 22 (8). S. 603 - 617. NEW YORK: SPRINGER. ISSN 1433-0415

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Abstract

Hodgkin lymphoma is the most frequent hematologic neoplasia in young adults. Most patients (> 80 %) can be healed with risk-adapted chemo- and/or radiotherapy. The staging into early favorable, early unfavorable, and advanced stages depends on tumor burden and other risk factors. A thorough and complete diagnosis is important for risk classification. State-of-the-art first-line therapies for early favorable and early unfavorable Hodgkin lymphoma are combined radiochemotherapies: In early favorable stages with two cycles of ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) and in early unfavorable with two cycles of BEACOPP(esc) (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, prednisolone, procarbazine) therapy followed by two cycles of ABVD. In advanced stages, radiotherapy after six cycles of BEACOPP(esc) therapy depends on residual metabolic activity after chemotherapy. With curative intent, first choice in relapse is high-dose chemotherapy. The special needs of young adults with cancer must be taken into consideration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Buerkle, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-268322
DOI:	10.1007/s00761-016-0057-x
Journal or Publication Title:	Onkologe
Volume:	22
Number:	8
Page Range:	S. 603 - 617
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0415
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; NON-INFERIORITY TRIAL; STUDY-GROUP GHSG; ELDERLY-PATIENTS; OPEN-LABEL; RADIOTHERAPY; DISEASE; RISK; PET; CHEMOTHERAPY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26832