Universität zu Köln

Kartashev, Vladimir, Doering, Matthias, Nieto, Leonardo ORCID: 0000-0002-1336-5645, Coletta, Eleda, Kaiser, Rolf and Sierra, Saleta (2016). New findings in HCV genotype distribution in selected West European, Russian and Israeli regions. J. Clin. Virol., 81. S. 82 - 90. AMSTERDAM: ELSEVIER. ISSN 1873-5967

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Abstract

Background: HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). Objectives: Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015. Study design: Anonymized information from 52 centers was analyzed retrospectively. Results: 37,839 samples were included in the study. We show that the GT distribution is similar throughout Western European countries, with some local differences. Here GTs 1 and 2 prevalences are lower and of GT4 higher than in all previous reports. Israel has a unique GT pattern and in South Russia the GT proportions are more similar to Asia. GTs 5 and 6 were detected in very low proportions. Three cases of the recombinant genotype P were reported in Munich (Germany). In addition, we observed that GT proportion was dependant on patients' gender, age and transmission route: GTs lb and 2 were significantly more common in female, older, nosocomially-infected patients, while GTs 1 a, 3 and 4 were more frequent in male, younger patients infected by tattooing, drug consume, and/or sexual practices. In infections acquired by drug consume, GTs la (35.0%) and 3 (28.1%) prevailed. In infections related to sexual practices lower proportion of GT3 (14.0%) and higher of GT4 (20.2%) were detected. GT4 was mostly abundant in MSM (29.6%). HIV coinfection was significantly associated with higher proportions GTs la and 4 (42.5% and 19.3%, respectively). Conclusion: Genotype prevalence evolves and correlates to epidemiological factors. Continuous surveillance is necessary to better assess hepatitis C infection in Europe and to take appropriate actions. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommongorggicenses/by-nc-nd/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kartashev, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Doering, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Nieto, Leonardo UNSPECIFIED orcid.org/0000-0002-1336-5645 UNSPECIFIED Coletta, Eleda UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Sierra, Saleta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-268544
DOI:	10.1016/j.jcv.2016.05.010
Journal or Publication Title:	J. Clin. Virol.
Volume:	81
Page Range:	S. 82 - 90
Date:	2016
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-5967
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATITIS-C VIRUS; II ASSAY; EPIDEMIOLOGY; HIV; COINFECTION; PREVALENCE; INFECTION; SUBTYPE; LIPA; ERA Multiple languages Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26854