Universität zu Köln

Dillen, Kim N. H., Jacobs, Heidi I. L., Kukolja, Juraj ORCID: 0000-0003-1569-3287, von Reutern, Boris, Richter, Nils, Onur, Ozgur A., Dronse, Julian, Langen, Karl-Josef ORCID: 0000-0003-1101-5075 and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2016). Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiol. Aging, 44. S. 114 - 127. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1558-1497

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Abstract

The posterior cingulate cortex (PCC) is a key hub of the default mode network, a resting-state network involved in episodic memory, showing functional connectivity (FC) changes in Alzheimer's disease (AD). However, PCC is a cytoarchitectonically heterogeneous region. Specifically, the retrosplenial cortex (RSC), often subsumed under the PCC, is an area functionally and microanatomically distinct from PCC. To investigate FC patterns of RSC and PCC separately, we used resting-state functional magnetic resonance imaging in healthy aging participants, patients with subjective cognitive impairment, and prodromal AD. Compared to the other 2 groups, we found higher FC from RSC to frontal cortex in subjective cognitive impairment but higher FC to occipital cortex in prodromal AD. Conversely, FC from PCC to the lingual gyrus was higher in prodromal AD. Furthermore, data indicate that RSC and PCC are characterized by differential FC patterns represented by hub-specific interactions with memory and attentions scores in prodromal AD compared to cognitively normal individuals, possibly reflecting compensatory mechanisms for RSC and neurodegenerative processes for PCC. Data thus confirm and extend previous studies suggesting that the RSC is functionally distinct from PCC. (C) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dillen, Kim N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Heidi I. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED von Reutern, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Richter, Nils UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Ozgur A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dronse, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269082
DOI:	10.1016/j.neurobiolaging.2016.04.010
Journal or Publication Title:	Neurobiol. Aging
Volume:	44
Page Range:	S. 114 - 127
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1558-1497
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; INDEPENDENT COMPONENT ANALYSIS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DEFAULT NETWORK; IN-VIVO; MEMORY; STATE; MODEL Multiple languages Geriatrics & Gerontology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26908