Universität zu Köln

Mengel, David, Dams, Judith, Ziemek, Jannis, Becker, Julian, Balzer-Geldsetzer, Monika, Hilker, Ruediger, Baudrexel, Simon, Kalbe, Elke, Schmidt, Nele, Witt, Karsten, Liepelt-Scarfone, Inga, Graeber, Susanne, Petrelli, Annette, Neuser, Petra, Schulte, Claudia ORCID: 0000-0003-4006-1265, Linse, Katharina, Storch, Alexander, Wittchen, Hans-Ulrich ORCID: 0000-0002-6311-7711, Riedel, Oliver, Mollenhauer, Brit, Ebentheuer, Jens, Treniwalder, Claudia, Klockgether, Thomas, Spottke, Annika, Wuellner, Ullrich, Schulz, Joerg B., Reetz, Kathrin, Heber, Ines Ann, Ramirez, Alfredo ORCID: 0000-0003-4991-763X and Dodel, Richard (2016). Apolipoprotein E epsilon 4 does not affect cognitive performance in patients with Parkinson's disease. Parkinsonism Relat. Disord., 29. S. 112 - 117. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: Cognitive impairment is a common and disabling non-motor symptom in Parkinson's disease (PD). The apolipoprotein E (APOE) allele epsilon 4 is a known risk factor for Alzheimer's disease and has also been suggested to be a risk factor for dementia in PD and even a predictor of impairment in certain cognitive domains. Methods: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-epsilon 4 and cognitive performance. Results: The APOE-epsilon 4 allele was not associated with a diagnosis of cognitive impairment in PD (PD with mild cognitive impairment and PD with dementia) or with deficits in specific neuropsychological domains in our study cohort. Conclusion: Our data question the relevance of the APOE-epsilon 4 allele as a predictor of cognitive impairment in PD. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mengel, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Dams, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziemek, Jannis UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Balzer-Geldsetzer, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker, Ruediger UNSPECIFIED UNSPECIFIED UNSPECIFIED Baudrexel, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Nele UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Liepelt-Scarfone, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeber, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrelli, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Neuser, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Claudia UNSPECIFIED orcid.org/0000-0003-4006-1265 UNSPECIFIED Linse, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, Hans-Ulrich UNSPECIFIED orcid.org/0000-0002-6311-7711 UNSPECIFIED Riedel, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, Brit UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebentheuer, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Treniwalder, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Klockgether, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuellner, Ullrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Joerg B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heber, Ines Ann UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Dodel, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269120
DOI:	10.1016/j.parkreldis.2016.04.013
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	29
Page Range:	S. 112 - 117
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEMENTIA; IMPAIRMENT; METAANALYSIS; APOE Multiple languages Clinical Neurology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26912