Universität zu Köln

Fengler, S., Roeske, S., Heber, I., Reetz, K., Schulz, J. B., Riedel, O., Wittchen, H. U., Storch, A., Linse, K., Baudrexel, S., Hilker, R., Mollenhauer, B., Witt, K., Schmidt, N., Balzer-Geldsetzer, M., Dams, J., Dodel, R., Graeber, S., Pilotto, A., Petrelli, A., Fuenkele, S., Kassubek, J. and Kalbe, E. (2016). Verbal memory declines more in female patients with Parkinson's disease: the importance of gender-corrected normative data. Psychol. Med., 46 (11). S. 2275 - 2287. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1469-8978

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Abstract

Background Data on gender-specific profiles of cognitive functions in patients with Parkinson's disease (PD) are rare and inconsistent, and possible disease-confounding factors have been insufficiently considered. Method The LANDSCAPE study on cognition in PD enrolled 656 PD patients (267 without cognitive impairment, 66% male; 292 with mild cognitive impairment, 69% male; 97 with PD dementia, 69% male). Raw values and age-, education-, and gender-corrected Z scores of a neuropsychological test battery (CERAD-Plus) were compared between genders. Motor symptoms, disease duration, l-dopa equivalent daily dose, depression - and additionally age and education for the raw value analysis - were taken as covariates. Results Raw-score analysis replicated results of previous studies in that female PD patients were superior in verbal memory (word list learning, p = 0.02; recall, p = 0.03), while men outperformed women in visuoconstruction (p = 0.002) and figural memory (p = 0.005). In contrast, gender-corrected Z scores showed that men were superior in verbal memory (word list learning, p = 0.02; recall, p = 0.02; recognition, p = 0.04), while no difference was found for visuospatial tests. This picture could be observed both in the overall analysis of PD patients as well as in a differentiated group analysis. Conclusions Normative data corrected for gender and other sociodemographic variables are relevant, since they may elucidate a markedly different cognitive profile compared to raw scores. Our study also suggests that verbal memory decline is stronger in women than in men with PD. Future studies are needed to replicate these findings, examine the progression of gender-specific cognitive decline in PD and define different underlying mechanisms of this dysfunction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fengler, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeske, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heber, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reetz, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, J. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittchen, H. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Storch, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Linse, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baudrexel, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hilker, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mollenhauer, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Witt, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Balzer-Geldsetzer, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dams, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dodel, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeber, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pilotto, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrelli, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuenkele, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalbe, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269178
DOI:	10.1017/S0033291716000908
Journal or Publication Title:	Psychol. Med.
Volume:	46
Number:	11
Page Range:	S. 2275 - 2287
Date:	2016
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1469-8978
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; DEMENTIA ASSESSMENT PANDA; KROLIKOWSKI ET-AL.; MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; SEX-DIFFERENCES; NONMOTOR FEATURES; INITIAL FINDINGS; CLINICAL CHARACTERISTICS; DIAGNOSTIC-CRITERIA Multiple languages Psychology, Clinical; Psychiatry; Psychology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26917