Universität zu Köln

Schweer, K. E., Jakob, B., Liss, B., Christ, H., Fischer, G., Vehreschild, M. J. G. T., Cornely, O. A. and Vehreschild, J. J. (2016). Domestic mould exposure and invasive aspergillosis-air sampling of Aspergillus spp. spores in homes of hematological patients, a pilot study. Med. Mycol., 54 (6). S. 576 - 584. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2709

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Abstract

Aspergillus spp.-related morbidity and mortality remains a major challenge in the management of neutropenic patients. Little is known about the impact of domestic Aspergillus spp. exposure. In this controlled prospective study, fungal spores were collected from homes of neutropenic patients. Cases were defined as patients with probable or proven controls as patients with no invasive pulmonary aspergillosis, while patients with possible disease were evaluated as a third group. Forty patients were enrolled and returned questionnaires on high-risk activities and mould exposure. A. fumigatus was detected in concentrations of 0 to 76 cfu/m(3) in every home. A. terreus was detected in nine (18%) homes. Mean Aspergillus spp. cfu/m(3) according to EORTC criteria were: proven/probable IA (15 patients) - 36; possible IA (12 patients) - 42; no IA (13 patients) - 42. Of the seven patients with self-reported moulded walls at home, four had probable and three had possible aspergillosis; the risk ratio of developing IA was 1.65 (95% CI: 1.25-2.17). In conclusion self-reported domestic mould exposure was associated with a high incidence of IA and may be a feasible tool for identifying high-risk patients. There was no correlation between domestic ambient-air spore counts and IA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schweer, K. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liss, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, M. J. G. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-269314
DOI:	10.1093/mmy/myw007
Journal or Publication Title:	Med. Mycol.
Volume:	54
Number:	6
Page Range:	S. 576 - 584
Date:	2016
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1460-2709
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NOSOCOMIAL ASPERGILLOSIS; COMPARATIVE PERFORMANCE; FUNGAL-INFECTIONS; INTENSIVE-CARE; INDOOR FUNGI; FUMIGATUS; CONTAMINATION; EPIDEMIOLOGY; CONSTRUCTION; ENVIRONMENT Multiple languages Infectious Diseases; Mycology; Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26931