Universität zu Köln

Baume, Norbert, Geyer, Hans, Vouillamoz, Marc, Grisdale, Richard, Earl, Mike, Aguilera, Rodrigo, Cowan, David A., Ericsson, Magnus, Gmeiner, Guenter, Kwiatkowska, Dorota, Kioukia-Fougia, Nassia, Molina, Adeline, Ruivo, Joao, Segura, Jordi, Van Eenoo, Peter, Jan, Nicolas, Robinson, Neil and Saugy, Martial (2016). Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013. Drug Test. Anal., 8 (7). S. 603 - 613. HOBOKEN: WILEY. ISSN 1942-7611

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Abstract

Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudoendogenous anabolic steroids. The steroidal module of the Athlete Biological Passport (ABP) was launched by the World Anti-Doping Agency (WADA) in 2014. To assess the value of introducing the module to its anti-doping programme, the Union of European Football Associations (UEFA) decided to analyze retrospectively the steroid profile data of 4195 urine samples, collected from 879 male football players and analyzed in 12 WADA-accredited laboratories between 2008 and mid-2013. This study focused on the evaluation of T/E ratios. The coefficient of variation (CV) and the adaptivemodel were the two statistical models used to study the longitudinal follow-up. A CV of 46% was determined to be themaximal natural intra-individual variation of the T/E when the sequence consisted of single data points analyzed in different laboratories. The adaptive model showed some profiles with an atypical T/E sequence and also enabled an estimate of the prevalence of external factors impacting the T/E sequences. Despite the limitations of this retrospective study, it clearly showed that the longitudinal and individual follow-up of the T/E biomarker of the players is a good tool for target testing in football. UEFA has therefore decided to implement the steroidal module of the ABP from the start of the next European football season in September 2015. Copyright (C) 2015 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baume, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Geyer, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Vouillamoz, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Grisdale, Richard UNSPECIFIED UNSPECIFIED UNSPECIFIED Earl, Mike UNSPECIFIED UNSPECIFIED UNSPECIFIED Aguilera, Rodrigo UNSPECIFIED UNSPECIFIED UNSPECIFIED Cowan, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ericsson, Magnus UNSPECIFIED UNSPECIFIED UNSPECIFIED Gmeiner, Guenter UNSPECIFIED UNSPECIFIED UNSPECIFIED Kwiatkowska, Dorota UNSPECIFIED UNSPECIFIED UNSPECIFIED Kioukia-Fougia, Nassia UNSPECIFIED UNSPECIFIED UNSPECIFIED Molina, Adeline UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruivo, Joao UNSPECIFIED UNSPECIFIED UNSPECIFIED Segura, Jordi UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Eenoo, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Jan, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Robinson, Neil UNSPECIFIED UNSPECIFIED UNSPECIFIED Saugy, Martial UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270251
DOI:	10.1002/dta.1851
Journal or Publication Title:	Drug Test. Anal.
Volume:	8
Number:	7
Page Range:	S. 603 - 613
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1942-7611
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATHLETE BIOLOGICAL PASSPORT; ENDOGENOUS URINARY STEROIDS; RATIO MASS-SPECTROMETRY; TESTOSTERONE ABUSE; T/E RATIO; POPULATION; MARKERS; SPORTS; MISUSE; POLYMORPHISM Multiple languages Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27025