Universität zu Köln

Demir, M., Foerster, U., Hoffmann, V., Pelc, A., Schreiter, I., Chang, D. -H., Krug, B., Christ, H. and Steffen, H. M. (2016). Effects of early contrast-enhanced computed tomography on clinical course and complications in patients with acute pancreatitis. Z. Gastroent., 54 (7). S. 642 - 647. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-7803

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Abstract

Purpose: To investigate the effect of an early contrast-enhanced computed tomography (CECT) on clinical course and complications of acute pancreatitis (AP). Material and Methods: 58 patients with AP who had at least one CECT examination were analyzed retrospectively. Laboratory as well as clinical data, and results from the assessment of disease severity (CT severity index (CTSI) and its modified (MCTSI) version) were analyzed. The primary endpoint was the development of severe complications, defined as death, respiratory failure, acute renal failure, and the need for invasive interventions. Patients were divided into two groups: an early group (CECT within the first 48 h after the onset of symptoms, n = 32) and a late group (CECT > 48 h after the onset of symptoms, n = 26). Multivariate regression analysis was performed to identify risk factors for severe complications. Results: There were no statistically significant differences between both groups concerning baseline characteristics, CTSI, and MCTSI. Complications occurred more often in the early CECT group (p = 0.008). Multivariate logistic regression analysis identified an early CECT and a severe MCTSI as independent risk factors for the occurrence of severe complications (p = 0.02 and p = 0.002, respectively). Conclusion: CECT performed within the first 48 h after the onset of symptoms is associated with an unfavorable outcome in AP.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Demir, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelc, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiter, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, D. -H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steffen, H. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270366
DOI:	10.1055/s-0042-101961
Journal or Publication Title:	Z. Gastroent.
Volume:	54
Number:	7
Page Range:	S. 642 - 647
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-7803
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE NECROTIZING PANCREATITIS; SEVERITY INDEX; UNITED-STATES; SCORING SYSTEMS; RISK-FACTOR; CT; RAT; MULTICENTER; CRITERIA Multiple languages Gastroenterology & Hepatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27036