Universität zu Köln

Lang, Nicolas ORCID: 0000-0002-0950-7727, Lange, Max, Schmitt, Friedhelm C. ORCID: 0000-0003-0361-9215, Boes, Monika, Weber, Yvonne, Evers, Stefan, Burghaus, Lothar, Kellinghaus, Christoph, Schubert-Bast, Susanne ORCID: 0000-0003-1545-7364, Boesel, Julian, Lammers, Thorsten, Sabolek, Michael, van Baalen, Andreas, Dziewas, Rainer ORCID: 0000-0003-1592-8461, Kraft, Andrea, Ruf, Susanne and Stephani, Ulrich (2016). Intravenous lacosamide in clinical practice-Results from an independent registry. Seizure, 39. S. 5 - 10. LONDON: W B SAUNDERS CO LTD. ISSN 1532-2688

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Abstract

Purpose: This non-interventional study was conducted to evaluate the efficacy and tolerability of intravenous lacosamide (LCM-iv) under routine conditions in daily clinical practice as a prospective registry. Methods: Patients with any type of seizure or epilepsy syndrome were recruited in 16 neurological and neuropediatric centers in Germany if the treating physician decided to administer LCM-iv for any reason. Observation time per patient was 10 days with daily documentation of LCM-iv administration, type and frequency of seizures, currently used drugs and doses, and adverse events. Treatment efficacy, tolerability, and handling of LCM-iv were assessed using a five-step scale. Results: In 119 patients treating physicians classified epilepsies as focal in 66.1% and generalized in 17.4% (16.5% unclassifiable). Most common etiologies of seizures were tumors (36.1%) and cerebrovascular diseases (21.8%). Reasons for LCM-iv treatment included preparation for surgery (25.2%), convulsive (24.4%) and non-convulsive (18.5%) status epilepticus (SE), series of seizures (16.0%), gastrointestinal causes (5.9%), and acute seizures (4.2%). The median dose of LCM-iv was 300 mg per day. In 45 of 64 patients (70.3%) with SE or series of seizures, epileptic activity ceased during observation time. Five patients showed abnormalities in ECG prior to the infusion and one patient afterwards, but during infusion no abnormalities were reported. Treating physicians rated efficacy and tolerability as very good or good in 77.6% and 93.1% of patients, respectively. Conclusions: This large and independent multicenter registry on the use of LCM-iv in clinical practice demonstrates that LCM-iv is well-tolerated and highly efficacious when given in emergency situations, including patients experiencing SE. It is advisable to perform an electrocardiogram prior to LCM-iv administration. (C) 2016 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lang, Nicolas UNSPECIFIED orcid.org/0000-0002-0950-7727 UNSPECIFIED Lange, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Friedhelm C. UNSPECIFIED orcid.org/0000-0003-0361-9215 UNSPECIFIED Boes, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Evers, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Burghaus, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Kellinghaus, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert-Bast, Susanne UNSPECIFIED orcid.org/0000-0003-1545-7364 UNSPECIFIED Boesel, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lammers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabolek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED van Baalen, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dziewas, Rainer UNSPECIFIED orcid.org/0000-0003-1592-8461 UNSPECIFIED Kraft, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruf, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephani, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-270882
DOI:	10.1016/j.seizure.2016.01.008
Journal or Publication Title:	Seizure
Volume:	39
Page Range:	S. 5 - 10
Date:	2016
Publisher:	W B SAUNDERS CO LTD
Place of Publication:	LONDON
ISSN:	1532-2688
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARTIAL-ONSET SEIZURES; NONCONVULSIVE STATUS EPILEPTICUS; RANDOMIZED CONTROLLED-TRIAL; ORAL LACOSAMIDE; ADJUNCTIVE THERAPY; EFFICACY; REPLACEMENT; CLUSTERS; ADULTS; SAFETY Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27088