Universität zu Köln

Merz, Maximilian, Jansen, Lina ORCID: 0000-0001-8004-4940, Castro, Felipe A., Hillengass, Jens, Salwender, Hans ORCID: 0000-0001-7803-0814, Weisel, Katja, Scheid, Christof, Luttmann, Sabine, Emrich, Katharina, Holleczek, Bernd, Katalinic, Alexander ORCID: 0000-0003-0490-1554, Nennecke, Alice, Straka, Christian, Langer, Christian, Engelhardt, Monika, Einsele, Hermann, Kroeger, Nicolaus, Beelen, Dietrich, Dreger, Peter, Brenner, Hermann ORCID: 0000-0002-6129-1572 and Goldschmidt, Hartmut (2016). Survival of elderly patients with multiple myeloma-Effect of upfront autologous stem cell transplantation. Eur. J. Cancer, 62. S. 1 - 9. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: The aim of this study was to determine the value of upfront autologous transplantation (ASCT) in elderly patients (60-79 years) with myeloma. Methods: We analysed relative survival (RS) of patients diagnosed in 1998-2011 and treated with ASCT within 12 months after diagnosis in Germany (n = 3591; German Registry of Stem Cell Transplantation) and compare RS with survival of myeloma patients diagnosed in the same years in Germany (n = 13,903; population-based German Cancer Registries). Results: Utilisation of ASCT has increased rapidly between 2000-2002 and 2009-2011 (60-64years: 7.0-43.0%; 65-69 years: 6.6-23.7%; 70-79 years: 0.4-4.0%). Comparison of 5-year RS of patients from the general German myeloma population who have survived the first year after diagnosis with 5-year RS of patients treated with ASCT revealed higher survival for transplanted patients among all age groups (60-64: 59.2% versus 66.1%; 65-69: 57.4% versus 61.7%; 70-79: 51.0% versus 56.6%). RS increased strongly between 2003-2005 and 2009 -2011 for the general German myeloma population (+8.5%) and for patients treated with ASCT (+11.8%). Differences in RS between these groups increased over time from +1.9% higher age-standardised survival in transplanted patients in 2003-2005 to 5.2% higher survival in 2009-2011. Conclusion: We conclude that upfront ASCT might be a major contributor to improved survival for elderly myeloma patients in Germany. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Merz, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Jansen, Lina UNSPECIFIED orcid.org/0000-0001-8004-4940 UNSPECIFIED Castro, Felipe A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillengass, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Salwender, Hans UNSPECIFIED orcid.org/0000-0001-7803-0814 UNSPECIFIED Weisel, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Luttmann, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Emrich, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Holleczek, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Katalinic, Alexander UNSPECIFIED orcid.org/0000-0003-0490-1554 UNSPECIFIED Nennecke, Alice UNSPECIFIED UNSPECIFIED UNSPECIFIED Straka, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelhardt, Monika UNSPECIFIED UNSPECIFIED UNSPECIFIED Einsele, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nicolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Beelen, Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Brenner, Hermann UNSPECIFIED orcid.org/0000-0002-6129-1572 UNSPECIFIED Goldschmidt, Hartmut UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271796
DOI:	10.1016/j.ejca.2016.04.004
Journal or Publication Title:	Eur. J. Cancer
Volume:	62
Page Range:	S. 1 - 9
Date:	2016
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1879-0852
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM SURVIVAL; UP-TO-DATE; CANCER SURVIVAL; PERIOD ANALYSIS; IMPROVEMENT; MELPHALAN; THERAPY Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27179