Universität zu Köln

Witkowski, Peter T. ORCID: 0000-0002-6167-8945, Drexler, Jan F., Kallies, Rene ORCID: 0000-0002-9195-0276, Lickova, Martina ORCID: 0000-0001-5357-6618, Bokorova, Silvia, Mananga, Gael D., Szemes, Tomas ORCID: 0000-0002-0900-2534, Leroy, Eric M., Krueger, Detlev H., Drosten, Christian and Klempa, Boris ORCID: 0000-0002-6931-1224 (2016). Phylogenetic analysis of a newfound bat-borne hantavirus supports a laurasiatherian host association for ancestral mammalian hantaviruses. Infect. Genet. Evol., 41. S. 113 - 120. AMSTERDAM: ELSEVIER. ISSN 1567-7257

Full text not available from this repository.

Abstract

Until recently, hantaviruses (family Bunyaviridae) were believed to originate from rodent reservoirs. However, genetically distinct hantaviruses were lately found in shrews and moles, as well as in bats from Africa and Asia. Bats (order Chiroptera) are considered important reservoir hosts for emerging human pathogens. Here, we report on the identification of a novel hantavirus, provisionally named Makokou virus (MAKV), in Noack's Roundleaf Bat (Hipposideros ruber) in Gabon, Central Africa. Phylogenetic analysis of the genomic L-segment showed that MAKV was the most closely related to other bat-borne hantaviruses and shared a most recent common ancestor with the Asian hantaviruses Xuan Son and Laibin. Breakdown of the virus load in a bat animal showed that MAKV resembles rodent-borne hantaviruses in its organ distribution in that it predominantly occurred in the spleen and kidney; this provides a first insight into the infection pattern of bat-borne hantaviruses. Ancestral state reconstruction based on a tree of L gene sequences of all relevant hantavirus lineages was combined with phylogenetic fossil host hypothesis testing, leading to a statistically significant rejection of the mammalian superorder Euarchontoglires (including rodents) but not the superorder Laurasiatheria (including shrews, moles, and bats) as potential hosts of ancestral hantaviruses at most basal tree nodes. Our data supports the emerging concept of bats as previously overlooked hantavirus reservoir hosts. (C) 2016 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Witkowski, Peter T. UNSPECIFIED orcid.org/0000-0002-6167-8945 UNSPECIFIED Drexler, Jan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kallies, Rene UNSPECIFIED orcid.org/0000-0002-9195-0276 UNSPECIFIED Lickova, Martina UNSPECIFIED orcid.org/0000-0001-5357-6618 UNSPECIFIED Bokorova, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Mananga, Gael D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Szemes, Tomas UNSPECIFIED orcid.org/0000-0002-0900-2534 UNSPECIFIED Leroy, Eric M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, Detlev H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drosten, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Klempa, Boris UNSPECIFIED orcid.org/0000-0002-6931-1224 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-271842
DOI:	10.1016/j.meegid.2016.03.036
Journal or Publication Title:	Infect. Genet. Evol.
Volume:	41
Page Range:	S. 113 - 120
Date:	2016
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1567-7257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIRUS; EVOLUTIONARY; MOUSE; SHREW Multiple languages Infectious Diseases Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27184