Universität zu Köln

Fuchs, W., Wieland, U., Skaletz-Rorowski, A., Brockmeyer, N. H., Swoboda, J., Kreuter, A., Michalik, C. and Potthoff, A. (2016). The male ScreenING Study: prevalence of HPV-related genital and anal lesions in an urban cohort of HIV-positive men in Germany. J. Eur. Acad. Dermatol. Venereol., 30 (6). S. 995 - 1002. HOBOKEN: WILEY. ISSN 1468-3083

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Abstract

Background Human papillomaviruses (HPV) induce condylomata, anogenital cancers and their precursor lesions as anal or penile intraepithelial neoplasia (AIN/PIN). HIV-positive individuals have an increased risk for the development of anogenital HPV-induced lesions. Objective Estimation of the prevalence of HPV-related anogenital benign and malignant lesions in HIV-infected men attending a screening programme. Methods Four hundred HIV-positive men [98% men who have sex with men (MSM)] were enrolled in this prospective study from 2008 to 2011. All patients received an inspection of the anogenital region, digital rectal examination, high-resolution anoscopy (HRA), anal cytology, anal/penile histology if required, and HPV-typing of anal and penile swabs. Results At baseline, 75% (n = 302) of the men had abnormal anal cytological/histological results. 41% presented with low-grade (n = 164), 24% with high-grade anal dysplasia (n = 95) and two men with invasive anal cancer. 2.3% had PIN (n = 9) and one patient had penile cancer at baseline. Throughout the study period, 75% had anal dysplasia (low-grade n = 177, high-grade n = 125), 3.3% (n = 13) had PIN and two further patients developed anal cancer. Within the study period, 52.8% (n = 211) had condylomata (49% anal, 15% penile, 11% anal plus penile condylomata). At baseline, 88.5% of anal and 39.3% of penile swabs were HPV-DNA positive, and 77.8% of anal and 26.5% of penile swabs carried high-risk HPV-types. HPV16 was the most frequent HPV-type. Conclusion HIV-positive MSM have a high risk for HPV-induced condylomata, (pre)malignant anogenital lesions and anogenital cancers. Screening for HPV-induced dysplasia is crucial to avoid progression to invasive carcinomas. Additionally, HPV-vaccination recommendations should be extended to high-risk populations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fuchs, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieland, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skaletz-Rorowski, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmeyer, N. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Swoboda, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuter, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Michalik, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Potthoff, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273094
DOI:	10.1111/jdv.13539
Journal or Publication Title:	J. Eur. Acad. Dermatol. Venereol.
Volume:	30
Number:	6
Page Range:	S. 995 - 1002
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1468-3083
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; PENILE INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS DNA; INFECTED MEN; UNITED-STATES; RISK-FACTORS; CANCER-RISK; HETEROSEXUAL MEN; HAART ERA; SEX Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27309