Universität zu Köln

Reichart, Florian, Horn, Mareike and Neundorf, Ines ORCID: 0000-0001-6450-3991 (2016). Cyclization of a cell-penetrating peptide via click-chemistry increases proteolytic resistance and improves drug delivery. J. Pept. Sci., 22 (6). S. 421 - 427. HOBOKEN: WILEY. ISSN 1099-1387

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Abstract

In this work we report synthesis and biological evaluation of a cell-penetrating peptide (CPP), that is partly cyclized via a triazole bridge. Recently, beneficious properties have been reported for cyclized peptides concerning their metabolic stability and intracellular uptake. A CPP based on human calcitonin was used in this study, and side chain cyclization was achieved via copper catalyzed alkyne-azide click reaction. Cell viability studies in several cell-lines revealed no cytotoxic effects. Furthermore, efficient uptake in breast cancer MCF-7 cells could be determined. Moreover, preliminary studies using this novel peptide as drug transporter for daunorubicin were performed. Copyright (c) 2016 European Peptide Society and John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reichart, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Horn, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273272
DOI:	10.1002/psc.2885
Journal or Publication Title:	J. Pept. Sci.
Volume:	22
Number:	6
Page Range:	S. 421 - 427
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1099-1387
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN CALCITONIN; CARRIER PEPTIDES; ACID Multiple languages Biochemistry & Molecular Biology; Chemistry, Analytical Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27327