Universität zu Köln

Janoschek, Ruth, Bae-Gartz, Inga, Vohlen, Christina, Alcazar, Miguel A. Alejandre, Dinger, Katharina, Appel, Sarah, Doetsch, Joerg and Hucklenbruch-Rother, Eva (2016). Dietary intervention in obese dams protects male offspring from WAT induction of TRPV4, adiposity, and hyperinsulinemia. Obesity, 24 (6). S. 1266 - 1274. HOBOKEN: WILEY-BLACKWELL. ISSN 1930-739X

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Abstract

ObjectiveOne major risk factor for childhood overweight is maternal obesity. The underlying molecular mechanisms are ill-defined, and effective prevention strategies are missing. MethodsDiet-induced obese mouse dams were changed to standard chow during pregnancy and lactation as an intervention against predisposition for obesity and metabolic sequelea in the offspring. Expression of adipokines and TRPV4, a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis, in offspring's white adipose tissue (WAT) was assessed. ResultsPathological effects on offspring's body weight, fat content, and serum insulin were fully reversed in intervention offspring on postnatal day 21. In WAT, a sixfold increase of Trpv4 mRNA expression in offspring consuming high-fat-containing diet was found, which was completely blunted in the intervention group. Simultaneously, WAT adipokine, interleukin-6, and peroxisome proliferator-activated receptor- mRNA and UCP1 protein expression were largely returned to control levels in intervention offspring. ConclusionsImprovement of maternal nutrition offers a powerful strategy to improve offspring's metabolic health. Targeting TRPV4-linked aspects of WAT metabolic function during early development might be a promising approach to prevent long-term adverse metabolic effects of maternal high-fat nutrition.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Janoschek, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Bae-Gartz, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Vohlen, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, Miguel A. Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Appel, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273686
DOI:	10.1002/oby.21486
Journal or Publication Title:	Obesity
Volume:	24
Number:	6
Page Range:	S. 1266 - 1274
Date:	2016
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1930-739X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-FAT DIET; MATERNAL OBESITY; INSULIN-RESISTANCE; PPAR-GAMMA; TISSUE; MICE; ADIPOCYTES; MODELS; BROWN; THERMOGENESIS Multiple languages Endocrinology & Metabolism; Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27368