Universität zu Köln

Schmidt, Elena ORCID: 0000-0003-0829-1423 and Kornfeld, Jan-Wilhelm ORCID: 0000-0002-6802-4442 (2016). Decoding Lamarck-transgenerational control of metabolism by noncoding RNAs. Pflugers Arch., 468 (6). S. 959 - 970. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-2013

Full text not available from this repository.

Abstract

The concept of epigenetic transgenerational inheritance (ETI) posits that lifetime experiences in parents, particularly fathers, alter the phenotypic trajectory of their progeny independently of Mendelian genetics. Based on evidence from population studies and laboratory-controlled studies in syngenic animals, this long-term discredited so-called Lamarckian inheritance gained prominent attention. This article aims to summarize the current knowledge about ETI in lower and in higher organisms as well as in human cohorts and elaborates on epigenetic principles potentially underlying this nongenetic mode of heredity. Special attention is given to-small and long-noncoding RNAs in male gametes that recently emerged as a molecular sensor of organismal metabolic states which can ultimately relay information across the germline barrier by translating environmental cues into (epigenetic) changes in zygotic gene expression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, Elena UNSPECIFIED orcid.org/0000-0003-0829-1423 UNSPECIFIED Kornfeld, Jan-Wilhelm UNSPECIFIED orcid.org/0000-0002-6802-4442 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273692
DOI:	10.1007/s00424-016-1807-8
Journal or Publication Title:	Pflugers Arch.
Volume:	468
Number:	6
Page Range:	S. 959 - 970
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-2013
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIET-INDUCED OBESITY; HIGH-FAT DIET; EPIGENETIC INHERITANCE; GENE-EXPRESSION; PRENATAL EXPOSURE; GENOME-WIDE; SPERM RNAS; LIFE-STYLE; LONG; DNA Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27369