Universität zu Köln

Platten, Martin, Jung, Norma, Trapp, Susanna, Flossdorf, Pia, Meyer-Olson, Dirk, zur Wiesch, Julian Schulze, Stephan, Christoph, Mauss, Stefan, Weiss, Verena, von Bergwelt-Baildon, Michael, Rockstroh, Juergen, Faetkenheuer, Gerd and Lehmann, Clara ORCID: 0000-0002-7042-1578 (2016). Cytokine and Chemokine Signature in Elite Versus Viremic Controllers Infected with HIV. Aids Res. Hum. Retrovir., 32 (6). S. 579 - 588. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1931-8405

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Abstract

HIV long-term nonprogressors (LTNPs) maintaining high CD4(+) T-cell counts without antiretroviral therapy (ART) are divided into elite controllers (ECs) with undetectable and viremic controllers (VCs) with low viral loads. Little is known about the long-term changes of T-cell subsets and inflammation patterns in ECs versus VCs. The aim of the study was to explore the long-term evolution of CD4(+) T-cell levels in LTNPs and to analyze cytokine profiles in ECs versus VCs. Nineteen ECs and 15 VCs were enrolled from the natural virus controller cohort (NaViC). T-cell counts were monitored over years, the mean annual change was calculated, and plasma concentrations of 25 cytokines were evaluated using a multiplex bead array. While absolute numbers of T cells did not differ between ECs and VCs over time, we observed a significant decrease of CD4(+) T-cell percentages in VCs, but not in ECs (median [interquartile range]: ECs: 37% [28-41] vs. VCs: 29% [25-34]; p=.02). ECs had lower levels of macrophage inflammatory protein-1 (MIP-1, p=.003), interferon -induced protein-10 (IP-10, p=.03), and monokine induced by interferon- (MIG, p=.02). CD4(+) T-cell percentages inversely correlated with MIP 1- (r=-0.42, p=.017) and IP-10 (r=-0.77, p<.0001). A subtle decline of CD4(+) T-cell percentages could be observed in VCs, but not in ECs, which was associated with higher plasma levels of proinflammatory cytokines. Hence, even low levels of HIV replication might go along with a progressive decline in CD4(+) T-cell counts in LTNPs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Platten, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Norma UNSPECIFIED UNSPECIFIED UNSPECIFIED Trapp, Susanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Flossdorf, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer-Olson, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED zur Wiesch, Julian Schulze UNSPECIFIED UNSPECIFIED UNSPECIFIED Stephan, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauss, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED von Bergwelt-Baildon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED orcid.org/0000-0002-7042-1578 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273732
DOI:	10.1089/aid.2015.0226
Journal or Publication Title:	Aids Res. Hum. Retrovir.
Volume:	32
Number:	6
Page Range:	S. 579 - 588
Date:	2016
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1931-8405
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; LONG-TERM NONPROGRESSORS; T-CELL HOMEOSTASIS; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; INDEPENDENT PREDICTORS; INDIVIDUALS; PROGRESSION; PERCENTAGE; EXPRESSION Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27373