Universität zu Köln

Wahba, Roger, Franke, Mareike, Hellmich, Martin, Kleinert, Robert, Cingoez, Tuelay, Schmidt, Matthias C., Stippel, Dirk L. and Bangard, Christopher (2016). Computed Tomography Volumetry in Preoperative Living Kidney Donor Assessment for Prediction of Split Renal Function. Transplantation, 100 (6). S. 1270 - 1278. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1534-6080

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Abstract

Background. Transplant centers commonly evaluate split renal function (SRF) with Tc-99m-mercapto-acetyltriglycin (MAG3) scintigraphy in living kidney donation. Alternatively, the kidney volume can be measured based on predonation CT scans. The aim of this study was to identify the most accurate CT volumetry technique for SRF and the prediction of postdonation kidney function (PDKF). Methods. Three CT volumetry techniques (modified ellipsoid volume [MELV], smart region of interest [ROI] volume, renal cortex volume [RCV]) were performed in 101 living kidney donors. Preoperation CT volumetric SRF was determined and compared with MAG3-SRF, postoperation donor kidney function, and graft function. Results. The correlation between donors predonation total kidney volume and predonation kidney function was the highest for RCV (0.58 with creatine clearance, 0.54 with estimated glomerular filtration rate-Cockcroft-Gault). The predonation volume of the preserved kidney was (ROI, MELV, RCV) 148.0 +/- 29.1 cm(3), 151.2 +/- 35.4 and 93.9 +/- 25.2 (P < 0.005 MELV vs RCV and ROI vs RCV). Bland-Altman analysis showed agreement between CT volumetry SRF and MAG3-SRF (bias, 95% limits of agreement: ROI vs MAG3 0.4%, -7.7% to 8.6%; MELV vs MAG3 0.4%, -8.9% to 9.7%; RCV vs MAG3 0.8%, -9.1% to 10.7%). The correlation between predonation CT volumetric SRF of the preserved kidney and PDKF at day 3 was r = 0.85 to 0.88, between MAG3-SRF and PDKF (r = 0.84). The difference of predonation SRF between preserved and donated kidney was the lowest for ROI and RCV (median, 3% and 4%; 95th percentile, 9% and 13%). Conclusions. Overall renal cortex volumetry seems to be the most accurate technique for the evaluation of predonation SRF and allows a reliable prediction of donor's PDKF.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wahba, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Mareike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleinert, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Cingoez, Tuelay UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Matthias C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stippel, Dirk L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bangard, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-273948
DOI:	10.1097/TP.0000000000000889
Journal or Publication Title:	Transplantation
Volume:	100
Number:	6
Page Range:	S. 1270 - 1278
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1534-6080
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-CAMERA RENOGRAPHY; TRANSPLANTATION; PARAMETERS Multiple languages Immunology; Surgery; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27394