Geisel, Marie H., Coassin, Stefan ORCID: 0000-0001-5677-8979, Hessler, Nicole, Bauer, Marcus, Eisele, Lewin, Erbel, Raimund, Haun, Margot, Hennig, Frauke, Moskau-Hartmann, Susanna, Hoffmann, Barbara, Joeckel, Karl-Heinz, Kedenko, Lyudmyla, Kiechl, Stefan, Kollerits, Barbara, Mahabadi, Amir-Abbas, Moebus, Susanne, Nuernberg, Gudrun, Nuernberg, Peter, Paulweber, Bernhard, Vens, Maren, Willeit, Johann, Willeit, Karin, Klockgether, Thomas, Ziegler, Andreas ORCID: 0000-0002-8386-5397, Scherag, Andre and Kronenberg, Florian ORCID: 0000-0003-2229-1120 (2016). Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study. Atherosclerosis, 249. S. 83 - 88. CLARE: ELSEVIER IRELAND LTD. ISSN 1879-1484

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Abstract

Carotid intima media thickness (cIMT) is a marker for subclinical atherosclerosis. The most recent genome-wide association meta-analysis (GWAMA) from the CHARGE consortium identified four genomic regions showing either significant (ZHX2, APOC1, PINX1) or suggestive evidence (SLC17A4) for an association. Here we assess these four cIMT loci in a pooled analysis of four independent studies including 5446 individuals by providing updated unbiased effect estimates of the cIMT association signals. The pooled estimates of our four independent samples pointed in the same direction and were similar to those of the GWAMA. When updating the independent second stage replication results from the earlier CHARGE GWAMA by our estimates, effect size estimates were closer to those of the original CHARGE discovery. A fine-mapping approach within a +/- 50 kb region around each lead SNP from CHARGE revealed 27 variants with larger estimated effect sizes than the lead SNPs but only three of them showed a r(2) > 0.40 with these respective lead SNPs from CHARGE. Some variants are located within potential functional loci. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Geisel, Marie H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coassin, StefanUNSPECIFIEDorcid.org/0000-0001-5677-8979UNSPECIFIED
Hessler, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisele, LewinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erbel, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haun, MargotUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hennig, FraukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moskau-Hartmann, SusannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joeckel, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kedenko, LyudmylaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiechl, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kollerits, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahabadi, Amir-AbbasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moebus, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paulweber, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vens, MarenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willeit, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Willeit, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klockgether, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ziegler, AndreasUNSPECIFIEDorcid.org/0000-0002-8386-5397UNSPECIFIED
Scherag, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kronenberg, FlorianUNSPECIFIEDorcid.org/0000-0003-2229-1120UNSPECIFIED
URN: urn:nbn:de:hbz:38-273989
DOI: 10.1016/j.atherosclerosis.2016.03.042
Journal or Publication Title: Atherosclerosis
Volume: 249
Page Range: S. 83 - 88
Date: 2016
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1879-1484
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; SUBCLINICAL ATHEROSCLEROSIS; LIPID-LEVELS; METAANALYSIS; HEART; POLYMORPHISMS; DISEASE; GENE; EPIDEMIOLOGY; ELEMENTSMultiple languages
Cardiac & Cardiovascular Systems; Peripheral Vascular DiseaseMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27398

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