Universität zu Köln

Ottens, Franziska ORCID: 0000-0002-0353-2649 and Gehring, Niels H. ORCID: 0000-0001-7792-1164 (2016). Physiological and pathophysiological role of nonsense-mediated mRNA decay. Pflugers Arch., 468 (6). S. 1013 - 1029. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-2013

Full text not available from this repository.

Abstract

Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a quality control mechanism that degrades irregular or faulty mRNAs. NMD mainly degrades mRNAs, which contain a premature termination codon (PTC) and therefore encode a truncated protein. Furthermore, NMD alters the expression of different types of cellular mRNAs, the so-called endogenous NMD substrates. In this review, we focus on the impact of NMD on cellular and molecular physiology. We specify key classes of NMD substrates and provide a detailed overview of the physiological function of gene regulation by NMD. We also describe different mechanisms of NMD substrate degradation and how the regulation of the NMD machinery affects cellular physiology. Finally, we outline the physiological functions of central NMD factors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ottens, Franziska UNSPECIFIED orcid.org/0000-0002-0353-2649 UNSPECIFIED Gehring, Niels H. UNSPECIFIED orcid.org/0000-0001-7792-1164 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274813
DOI:	10.1007/s00424-016-1826-5
Journal or Publication Title:	Pflugers Arch.
Volume:	468
Number:	6
Page Range:	S. 1013 - 1029
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-2013
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXON JUNCTION COMPLEX; UNFOLDED PROTEIN RESPONSE; HERMANSKY-PUDLAK-SYNDROME; TRACT-BINDING-PROTEINS; STEM-CELL; NEURONAL DIFFERENTIATION; TRANSLATION INITIATION; REGULATORY SWITCH; GENE-EXPRESSION; AXON GUIDANCE Multiple languages Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27481