Universität zu Köln

Bois, C., Levita, L., Rippc, I., Owens, D. C. G., Johnstone, E. C., Whalley, H. C. and Lawrie, S. M. (2016). Longitudinal changes in hippocampal volume in the Edinburgh High Risk Study of Schizophrenia. Schizophr. Res., 173 (3). S. 146 - 152. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterations may be evident at any given time-point, or whether they progress over time. To investigate this, structural brain scans were acquired at two time-points (mean scan-interval 1.87 years) in a cohort of young unaffected individuals at high familial risk of schizophrenia (baseline, n = 142; follow-up, n = 64) and healthy controls (baseline, n = 36; follow-up, n = 18). Sub-cortical reconstructions of the hippocampus and amygdala were generated using the longitudinal pipeline available with Freesurfer. The high risk cohort was subdivided into individuals that remained well during the study (HR[well], baseline, n = 68; follow-up, n = 30), transient and/or partial symptoms that were insufficient to support a formal diagnosis (HR[symp], baseline, n = 57; follow-up, n = 26) and individuals that subsequently developed schizophrenia according to ICD-10 criteria (HR[ill], baseline, n = 17; follow-up, n = 8). Longitudinal change in the hippocampus and amygdala was compared, focusing first on overall differences between high-risk individuals and controls and then on sub-group differences within the high-risk cohort. We found a significantly altered developmental trajectory for all high risk individuals compared to controls, with controls showing a significant increase in hippocampal volume over time compared to those at high risk. We did not find evidence of altered longitudinal trajectories based on clinical outcome within the high risk cohort. These results suggest that an altered developmental trajectory of hippocampal volume is associated with a general familial predisposition to develop schizophrenia, as this alteration was not related to subsequent clinical outcome. (C) 2014 Published by Elsevier B.V.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bois, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Levita, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rippc, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Owens, D. C. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Johnstone, E. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Whalley, H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawrie, S. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-274888
DOI:	10.1016/j.schres.2014.12.003
Journal or Publication Title:	Schizophr. Res.
Volume:	173
Number:	3
Page Range:	S. 146 - 152
Date:	2016
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2509
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRAIN-DEVELOPMENT; TEMPORAL-LOBE; MATTER; METAANALYSIS; PSYCHOSIS; AMYGDALA; GRAY; MRI; ONSET Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27488