Universität zu Köln

Stegmayr, Carina ORCID: 0000-0003-4191-8734, Schoneck, Michael, Oliveira, Dennis, Willuweit, Antje ORCID: 0000-0002-6725-0755, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Shah, N. Jon ORCID: 0000-0002-8151-6169, Coenen, Heinz H. and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2016). Reproducibility of O-(2-F-18-fluoroethyl)-L-tyrosine uptake kinetics in brain tumors and influence of corticoid therapy: an experimental study in rat gliomas. Eur. J. Nucl. Med. Mol. Imaging, 43 (6). S. 1115 - 1124. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Positron emission tomography (PET) using O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) is a well-established method for the diagnostics of brain tumors. This study investigates reproducibility of F-18-FET uptake kinetics in rat gliomas and the influence of the frequently used dexamethasone (Dex) therapy. F98 glioma or 9L gliosarcoma cells were implanted into the striatum of 31 Fischer rats. After 10-11 days of tumor growth, the animals underwent dynamic PET after injection of F-18-FET (baseline). Thereafter, animals were divided into a control group and a group receiving Dex injections, and all animals were reinvestigated 2 days later. Tumor-to-brain ratios (TBR) of F-18-FET uptake (18-61 min p.i.) and the slope of the time-activity-curves (TAC) (18-61 min p.i.) were evaluated using a Volume-of-Interest (VOI) analysis. Data were analyzed by two-way repeated measures ANOVA and reproducibility by the intraclass correlation coefficient (ICC). The slope of the tumor TACs showed high reproducibility with an ICC of 0.93. A systematic increase of the TBR in the repeated scans was noted (3.7 +/- 2.8 %; p < 0.01), and appeared to be related to tumor growth as indicated by a significant correlation of TBR and tumor volume (r = 0.77; p < 0.0001). After correction for tumor growth TBR showed high longitudinal stability with an ICC of 0.84. Dex treatment induced a significant decrease of the TBR (-8.2 +/- 6.1 %; p < 0.03), but did not influence the slope of the tumor TAC. TBR of F-18-FET uptake and tracer kinetics in brain tumors showed high longitudinal stability. Dex therapy may induce a minor decrease of the TBR; this needs further investigation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Stegmayr, Carina UNSPECIFIED orcid.org/0000-0003-4191-8734 UNSPECIFIED Schoneck, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Oliveira, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED Willuweit, Antje UNSPECIFIED orcid.org/0000-0002-6725-0755 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Shah, N. Jon UNSPECIFIED orcid.org/0000-0002-8151-6169 UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-275034
DOI:	10.1007/s00259-015-3274-4
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	43
Number:	6
Page Range:	S. 1115 - 1124
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; VALUABLE DIAGNOSTIC-TOOL; HIGH-GRADE GLIOMA; AMINO-ACIDS; INTRACRANIAL TUMORS; CEREBRAL GLIOMAS; PROGNOSTIC VALUE; F-18-FET PET; FET PET; MRI Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27503