Universität zu Köln

Ferretti, Luca ORCID: 0000-0001-7578-7301, Schmiegelt, Benjamin, Weinreich, Daniel, Yamauchi, Atsushi ORCID: 0000-0002-8463-3491, Kobayashi, Yutaka, Tajima, Fumio and Achaz, Guillaume (2016). Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations. J. Theor. Biol., 396. S. 132 - 144. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1095-8541

Full text not available from this repository.

Abstract

Genotypic fitness landscapes are constructed by assessing the fitness of all possible combinations of a given number of mutations. In the last years, several experimental fitness landscapes have been completely resolved. As fitness landscapes are high-dimensional, simple measures of their structure are used as statistics in empirical applications. Epistasis is one of the most relevant features of fitness landscapes. Here we propose a new natural measure of the amount of epistasis based on the correlation of fitness effects of mutations. This measure has a natural interpretation, captures well the interaction between mutations and can be obtained analytically for most landscape models. We discuss how this measure is related to previous measures of epistasis (number of peaks, roughness/slope, fraction of sign epistasis, Fourier Walsh spectrum) and how it can be easily extended to landscapes with missing data or with fitness ranks only. Furthermore, the dependence of the correlation of fitness effects on mutational distance contains interesting information about the patterns of epistasis. This dependence can be used to uncover the amount and nature of epistatic interactions in a landscape or to discriminate between different landscape models. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ferretti, Luca UNSPECIFIED orcid.org/0000-0001-7578-7301 UNSPECIFIED Schmiegelt, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinreich, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Yamauchi, Atsushi UNSPECIFIED orcid.org/0000-0002-8463-3491 UNSPECIFIED Kobayashi, Yutaka UNSPECIFIED UNSPECIFIED UNSPECIFIED Tajima, Fumio UNSPECIFIED UNSPECIFIED UNSPECIFIED Achaz, Guillaume UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-275830
DOI:	10.1016/j.jtbi.2016.01.037
Journal or Publication Title:	J. Theor. Biol.
Volume:	396
Page Range:	S. 132 - 144
Date:	2016
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1095-8541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACCESSIBLE PATHS; MODEL; EVOLUTION Multiple languages Biology; Mathematical & Computational Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27583