Universität zu Köln

Franz, Andre, Ackermann, Leena ORCID: 0000-0001-6405-900X and Hoppe, Thorsten ORCID: 0000-0002-4734-9352 (2016). Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin. Front. Genet., 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

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Abstract

The dynamic composition of proteins associated with nuclear DNA is a fundamental property of chromosome biology. In the chromatin compartment dedicated protein complexes govern the accurate synthesis and repair of the genomic information and define the state of DNA compaction in vital cellular processes such as chromosome segregation or transcription. Unscheduled or faulty association of protein complexes with DNA has detrimental consequences on genome integrity. Consequently, the association of protein complexes with DNA is remarkably dynamic and can respond rapidly to cellular signaling events, which requires tight spatiotemporal control. In this context, the ring-like AAA+ ATPase CDC48/p97 emerges as a key regulator of protein complexes that are marked with ubiquitin or SUMO. Mechanistically, CDC48/p97 functions as a segregase facilitating the extraction of substrate proteins from the chromatin. As such, CDC48/p97 drives molecular reactions either by directed disassembly or rearrangement of chromatin-bound protein complexes. The importance of this mechanism is reflected by human pathologies linked to p97 mutations, including neurodegenerative disorders, oncogenesis, and premature aging. This review focuses on the recent insights into molecular mechanisms that determine CDC48/p97 function in the chromatin environment, which is particularly relevant for cancer and aging research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Franz, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Ackermann, Leena UNSPECIFIED orcid.org/0000-0001-6405-900X UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276008
DOI:	10.3389/fgene.2016.00073
Journal or Publication Title:	Front. Genet.
Volume:	7
Date:	2016
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-8021
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VALOSIN-CONTAINING PROTEIN; DNA-DAMAGE RESPONSE; NUCLEOTIDE EXCISION-REPAIR; DOUBLE-STRAND BREAKS; CROSS-LINK REPAIR; UBIQUITIN-SELECTIVE CHAPERONE; RNA-POLYMERASE-II; P97 AAA-ATPASE; GENOME STABILITY; REPLICATION FORK Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27600