Universität zu Köln

Peinemann, F., van Dalen, E. C. and Berthold, F. (2016). Retinoic Acid for High-risk Neuroblastoma Patients after Autologous Stem Cell Transplantation Cochrane Review. Klinische Padiatr., 228 (3). S. 124 - 130. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Background: Neuroblastoma is a rare malignant disease and patients with high-risk neuroblastoma have a poor prognosis. Retinoic acid has been shown to inhibit growth of human neuroblastoma cells and has been considered as a potential candidate for improving the outcome. Methods: The objective was to evaluate effects of retinoic acid after consolidation with high-dose chemotherapy and bone marrow transplantation as compared to placebo or no further treatment in patients with high-risk neuroblastoma. We searched the databases CENTRAL, MEDLINE, and EMBASE from inception to 01 October 2014 and included randomized controlled trials. Results: We identified one relevant randomized controlled trial with 50 participants receiving retinoic acid and 48 participants receiving no further therapy. There was no statistically significant difference between the treatment groups in overall survival (hazard ratio 0.87, 95 % confidence interval 0.46-1.63, P = 0.66) and event-free survival (hazard ratio 0.86, 95 % confidence interval 0.50-1.49, P = 0.59). We did not identify results for other outcomes, including toxicity. Conclusion: The difference in overall and event-free survival between treatment alternatives was not statistically significantly different. Based on the currently available evidence, we are uncertain about the effects of retinoic acid after bone marrow transplantation in patients with high-risk neuroblastoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peinemann, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dalen, E. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276823
DOI:	10.1055/s-0042-101169
Journal or Publication Title:	Klinische Padiatr.
Volume:	228
Number:	3
Page Range:	S. 124 - 130
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 13-CIS-RETINOIC ACID; CHILDREN; CLASSIFICATION; THERAPY; TRIAL Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27682