Universität zu Köln

Peinemann, F., van Dalen, E. C. and Berthold, F. (2016). Rapid COJEC Induction Therapy for High-risk Neuroblastoma Patients - Cochrane Review. Klinische Padiatr., 228 (3). S. 130 - 135. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3824

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Abstract

Background: Neuroblastoma is a rare malignant disease and patients with high-risk neuroblastoma have a poor prognosis. Rapid COJEC induction chemotherapy means (almost) the same total doses given within a shorter time period. In theory, rapid COJEC could reduce the risk of drug resistance and it has been considered as a potential candidate for improving the outcome. Methods: The objective was to evaluate effects of rapid COJEC compared to standard induction chemotherapy in patients with high-risk neuroblastoma. We searched the databases CENTRAL, MEDLINE, and EMBASE from inception to 11 November 2014 and included randomized controlled trials. Results: We identified one relevant randomized controlled trial with 130 participants receiving rapid COJEC and 132 participants receiving standard OPEC/COJEC induction chemotherapy. There was no statistically significant difference between the treatment groups in complete response (risk ratio 0.99, 95 % confidence interval 0.71 to 1.38, P = 0.94) and treatment-related mortality (risk ratio 1.21, 95 % confidence interval 0.33 to 4.39, P = 0.77). A statistically significant difference in favor of the standard treatment arm was identified for the following early toxicities: febrile neutropenia, septicemia, and renal toxicity. Conclusion: The differences in complete response and treatment-related mortality between treatment alternatives were not statistically significantly different. Based on the currently available evidence, we are uncertain about the effects of rapid COJEC induction chemotherapy in patients with high-risk neuroblastoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peinemann, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dalen, E. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276839
DOI:	10.1055/s-0042-103158
Journal or Publication Title:	Klinische Padiatr.
Volume:	228
Number:	3
Page Range:	S. 130 - 135
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3824
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27683