Universität zu Köln

Wendler, J. J., Friebe, B., Baumunk, D., Blana, A., Franiel, T., Ganzer, R., Hadaschik, B., Henkel, T., Koehrmann, K. U., Koellermann, J., Kuru, T., Machtens, S., Roosen, A., Salomon, G., Schlemmer, H. P., Sentker, L., Witzsch, U., Liehr, U. B., Ricke, J. and Schostak, M. (2016). Focal therapy for small renal masses. Observation, ablation or surgery. Urologe, 55 (5). S. 594 - 604. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

The rising incidence of renal cell carcinoma, its more frequent early detection (stage T1a) and the increasing prevalence of chronic renal failure with higher morbidity and shorter life expectancy underscore the need for multimodal focal nephron-sparing therapy. During the past decade, the gold standard shifted from radical to partial nephrectomy. Depending on the surgeon's experience, the patient's constitution and the tumor's location, the intervention can be performed laparoscopically with the corresponding advantages of lower invasiveness. A treatment alternative can be advantageous for selected patients with high morbidity and/or an increased risk of complications associated with anesthesia or surgery. Corresponding risk stratification necessitates previous confirmation of the small renal mass (cT1a) by histological examination of biopsy samples. Active surveillance represents a controlled delay in the initiation of treatment. Percutaneous radiofrequency ablation (RFA) and laparoscopic cryoablation are currently the most common treatment alternatives, although there are limitations particularly for renal tumors located centrally near the hilum. More recent ablation procedures such as high intensity focused ultrasound (HIFU), irreversible electroporation, microwave ablation, percutaneous stereotactic ablative radiotherapy and high-dose brachytherapy have high potential in some cases but are currently regarded as experimental for the treatment of renal cell carcinoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wendler, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friebe, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumunk, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blana, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Franiel, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ganzer, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadaschik, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henkel, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehrmann, K. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koellermann, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuru, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Machtens, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roosen, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salomon, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlemmer, H. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sentker, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Witzsch, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liehr, U. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ricke, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schostak, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-276874
DOI:	10.1007/s00120-016-0075-8
Journal or Publication Title:	Urologe
Volume:	55
Number:	5
Page Range:	S. 594 - 604
Date:	2016
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LAPAROSCOPIC PARTIAL NEPHRECTOMY; INTENSITY FOCUSED ULTRASOUND; CELL CARCINOMA RCC; RADIOFREQUENCY ABLATION; MICROWAVE ABLATION; IRREVERSIBLE ELECTROPORATION; ONCOLOGIC OUTCOMES; COMPUTED-TOMOGRAPHY; TUMORS; CRYOABLATION Multiple languages Urology & Nephrology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27687