Universität zu Köln

Bae-Gartz, Inga, Janoschek, Ruth, Kloppe, Cora-Sophia, Vohlen, Christina, Roels, Frederik, Oberthuer, Andre, Alcazar, Miguel Angel Alejandre, Lippach, Gregor ORCID: 0000-0002-7658-8299, Muether, Philipp S., Dinger, Katharina, Ferrari, Nina, Graf, Christine, Doetsch, Joerg and Hucklenbruch-Rother, Eva (2016). Running Exercise in Obese Pregnancies Prevents IL-6 Trans-signaling in Male Offspring. Med. Sci. Sports Exerc., 48 (5). S. 829 - 839. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1530-0315

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Abstract

Purpose: Maternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic dysfunction. Because preventive approaches in this context are missing to date, we aimed to identify molecular mechanisms in the offspring that are affected by maternal exercise during pregnancy. Methods: Diet-induced obese mouse dams were divided into a sedentary obese (high-fat diet [HFD]) group and an obese intervention (HFD-running intervention [RUN]) group, which performed voluntary wheel running throughout gestation. Male offspring were compared with the offspring of a sedentary lean control group at postnatal day 21. Results: HFD and HFD-RUN offspring showed increased body weight and white adipose tissue mass. Glucose tolerance testing showed mild impairment only in HFD offspring. Serum interleukin-6 (IL-6) levels, hypothalamic and white adipose tissue IL-6 gene expressions, and phosphorylation of signal transducer and activator of transcription 3 in HFD offspring were significantly increased, whereas HFD-RUN was protected against these changes. The altered hypothalamic global gene expression in HFD offspring showed partial normalization in HFD-RUN offspring, especially with respect to IL-6 action. Conclusion: Maternal exercise in obese pregnancies effectively reduces IL-6 trans-signaling and might be the underlying mechanism for the amelioration of glucose metabolism at postnatal day 21 independent of body composition.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bae-Gartz, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Janoschek, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloppe, Cora-Sophia UNSPECIFIED UNSPECIFIED UNSPECIFIED Vohlen, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Roels, Frederik UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberthuer, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Alcazar, Miguel Angel Alejandre UNSPECIFIED UNSPECIFIED UNSPECIFIED Lippach, Gregor UNSPECIFIED orcid.org/0000-0002-7658-8299 UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dinger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferrari, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Hucklenbruch-Rother, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277116
DOI:	10.1249/MSS.0000000000000835
Journal or Publication Title:	Med. Sci. Sports Exerc.
Volume:	48
Number:	5
Page Range:	S. 829 - 839
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1530-0315
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GESTATIONAL DIABETES-MELLITUS; CENTRAL-NERVOUS-SYSTEM; MATERNAL OBESITY; HYPOTHALAMIC INFLAMMATION; METABOLIC DISEASE; PHYSICAL-ACTIVITY; HEPATIC GLUCOSE; BIRTH-WEIGHT; SHORT-TERM; WOMEN Multiple languages Sport Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27711