Universität zu Köln

Toth, Csaba, Meinrath, Jeannine, Herpel, Esther, Derix, Jutta, Fries, Jochen ORCID: 0000-0003-2054-6345, Buettner, Reinhard, Schirmacher, Peter and Heikaus, Sebastian (2016). Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. J. Cancer Res. Clin. Oncol., 142 (5). S. 927 - 936. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

Apoptotic signaling is one of the most important processes in the measurement of chemotherapeutic effectiveness. In apoptotic machinery, various pathways and proteins are involved (i.e., mismatch repair proteins, p53). One of the regulatory proteins is ARC, which can inhibit not only the extrinsic but also the intrinsic apoptotic signaling. In this study, we investigated the expression levels of ARC in colorectal liver metastasis and compared them with the expression of mismatch repair proteins and p53. Furthermore, we investigated ARC expression level depending on sex, age, tumor grade, mucin production, tumor size and number of liver metastasis. ARC expression level in colorectal cancer liver metastasis was independent from clinical data (i.e., age, gender, tumor size, tumor number or mucin production) but strongly correlated with MSH2 and MSH6 expression, which further supported the evidence for the regulatory role of MSH2 and MSH6 in apoptosis; i.e., in case of sufficient MSH2 and MSH6 expression, significantly higher ARC level is required to suppress the apoptosis. A regulatory interaction between ARC and p53 has been described, but we found no correlation between p53 expression levels and ARC levels. Further studies are needed to define the exact role of ARC in apoptotic signaling and thus its role in chemoresistance and survival of tumor cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Toth, Csaba UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinrath, Jeannine UNSPECIFIED UNSPECIFIED UNSPECIFIED Herpel, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Derix, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Fries, Jochen UNSPECIFIED orcid.org/0000-0003-2054-6345 UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirmacher, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Heikaus, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277413
DOI:	10.1007/s00432-015-2102-3
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	142
Number:	5
Page Range:	S. 927 - 936
Date:	2016
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-DEATH; INHIBITOR ARC; RESISTANCE; RADIATION; PATHWAYS; NUCLEAR Multiple languages Oncology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27741