Zhao, Zhiguo, Wen, Wanqing, Michailidou, Kyriaki
ORCID: 0000-0001-7065-1237, Bolla, Manjeet K., Wang, Qin, Zhang, Ben, Long, Jirong
ORCID: 0000-0002-7433-9766, Shu, Xiao-Ou, Schmidt, Marjanka K., Milne, Roger L., Garcia-Closas, Montserrat, Chang-Claude, Jenny, Lindstrom, Sara, Bojesen, Stig E., Ahsan, Habibul, Aittomaki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker
ORCID: 0000-0001-9320-8684, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Blomqvist, Carl
ORCID: 0000-0003-3041-1938, Bogdanova, Natalia V., Borresen-Dale, Anne-Lise, Brand, Judith, Brauch, Hiltrud
ORCID: 0000-0001-7531-2736, Brenner, Hermann
ORCID: 0000-0002-6129-1572, Burwinkel, Barbara, Cai, Qiuyin, Casey, Graham, Chenevix-Trench, Georgia
ORCID: 0000-0002-1878-2587, Couch, Fergus J., Cox, Angela
ORCID: 0000-0002-5138-1099, Cross, Simon S., Czene, Kamila, Doerk, Thilo, Dumont, Martine, Fasching, Peter A., Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia
ORCID: 0000-0001-9387-7116, Flyger, Henrik, Fostira, Florentia, Gammon, Marilie, Giles, Graham G., Guenel, Pascal
ORCID: 0000-0002-8359-518X, Haiman, Christopher A., Hamann, Ute, Harrington, Patricia, Hartman, Mikael
ORCID: 0000-0001-5726-9965, Hooning, Maartje J., Hopper, John L., Jakubowska, Anna
ORCID: 0000-0002-5650-0501, Jasmine, Farzana, John, Esther M., Johnson, Nichola, Kabisch, Maria, Khan, Sofia
ORCID: 0000-0003-4185-8882, Kibriya, Muhammad, Knight, Julia A., Kosma, Veli-Matti, Kriege, Mieke, Kristensen, Vessela, Le Marchand, Loic, Lee, Eunjung, Li, Jingmei
ORCID: 0000-0001-8587-7511, Lindblom, Annika, Lophatananon, Artitaya, Luben, Robert, Lubinski, Jan
ORCID: 0000-0003-2931-3003, Malone, Kathleen E., Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Marme, Frederik, McLean, Catriona, Meijers-Heijboer, Hanne, Meindl, Alfons, Miao, Hui, Muir, Kenneth, Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Olson, Janet E., Perkins, Barbara, Peterlongo, Paolo
ORCID: 0000-0001-6951-6855, Phillips, Kelly-Anne
ORCID: 0000-0002-0475-1771, Pylkas, Katri
ORCID: 0000-0002-2449-0521, Rudolph, Anja, Santella, Regina, Sawyer, Elinor J., Schmutzler, Rita K., Schoemaker, Minouk
ORCID: 0000-0001-8403-2234, Shah, Mitul, Shrubsole, Martha
ORCID: 0000-0002-5591-7575, Southey, Melissa C., Swerdlow, Anthony J., Toland, Amanda E., Tomlinson, Ian, Torres, Diana, Ursin, Giske
ORCID: 0000-0002-0835-9507, Van Der Luijt, Rob B., Verhoef, Senno, Wang-Gohrke, Shan, Whittemore, Alice S., Winqvist, Robert, Zamora, M. Pilar, Zhao, Hui, Dunning, Alison M., Simard, Jacques, Hall, Per, Kraft, Peter
ORCID: 0000-0002-4472-8103, Pharoah, Paul
ORCID: 0000-0001-8494-732X, Hunter, David, Easton, Douglas F. and Zheng, Wei
ORCID: 0000-0003-1226-070X
(2016).
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Cancer Causes Control, 27 (5).
S. 679 - 694.
DORDRECHT:
SPRINGER.
ISSN 1573-7225
Full text not available from this repository.
Abstract
Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies. The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04). We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Zhao, Zhiguo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wen, Wanqing | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Michailidou, Kyriaki | UNSPECIFIED | orcid.org/0000-0001-7065-1237 | UNSPECIFIED | Bolla, Manjeet K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang, Qin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhang, Ben | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Long, Jirong | UNSPECIFIED | orcid.org/0000-0002-7433-9766 | UNSPECIFIED | Shu, Xiao-Ou | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmidt, Marjanka K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Milne, Roger L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Garcia-Closas, Montserrat | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chang-Claude, Jenny | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lindstrom, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bojesen, Stig E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ahsan, Habibul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aittomaki, Kristiina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Andrulis, Irene L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Anton-Culver, Hoda | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Arndt, Volker | UNSPECIFIED | orcid.org/0000-0001-9320-8684 | UNSPECIFIED | Beckmann, Matthias W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beeghly-Fadiel, Alicia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Benitez, Javier | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blomqvist, Carl | UNSPECIFIED | orcid.org/0000-0003-3041-1938 | UNSPECIFIED | Bogdanova, Natalia V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Borresen-Dale, Anne-Lise | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brand, Judith | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brauch, Hiltrud | UNSPECIFIED | orcid.org/0000-0001-7531-2736 | UNSPECIFIED | Brenner, Hermann | UNSPECIFIED | orcid.org/0000-0002-6129-1572 | UNSPECIFIED | Burwinkel, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cai, Qiuyin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Casey, Graham | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chenevix-Trench, Georgia | UNSPECIFIED | orcid.org/0000-0002-1878-2587 | UNSPECIFIED | Couch, Fergus J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cox, Angela | UNSPECIFIED | orcid.org/0000-0002-5138-1099 | UNSPECIFIED | Cross, Simon S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Czene, Kamila | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Doerk, Thilo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dumont, Martine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fasching, Peter A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Figueroa, Jonine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Flesch-Janys, Dieter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fletcher, Olivia | UNSPECIFIED | orcid.org/0000-0001-9387-7116 | UNSPECIFIED | Flyger, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fostira, Florentia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gammon, Marilie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Giles, Graham G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Guenel, Pascal | UNSPECIFIED | orcid.org/0000-0002-8359-518X | UNSPECIFIED | Haiman, Christopher A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hamann, Ute | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Harrington, Patricia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hartman, Mikael | UNSPECIFIED | orcid.org/0000-0001-5726-9965 | UNSPECIFIED | Hooning, Maartje J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hopper, John L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jakubowska, Anna | UNSPECIFIED | orcid.org/0000-0002-5650-0501 | UNSPECIFIED | Jasmine, Farzana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | John, Esther M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johnson, Nichola | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kabisch, Maria | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Khan, Sofia | UNSPECIFIED | orcid.org/0000-0003-4185-8882 | UNSPECIFIED | Kibriya, Muhammad | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Knight, Julia A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kosma, Veli-Matti | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kriege, Mieke | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kristensen, Vessela | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Le Marchand, Loic | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lee, Eunjung | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Jingmei | UNSPECIFIED | orcid.org/0000-0001-8587-7511 | UNSPECIFIED | Lindblom, Annika | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lophatananon, Artitaya | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Luben, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lubinski, Jan | UNSPECIFIED | orcid.org/0000-0003-2931-3003 | UNSPECIFIED | Malone, Kathleen E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mannermaa, Arto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Manoukian, Siranoush | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Margolin, Sara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marme, Frederik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | McLean, Catriona | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meijers-Heijboer, Hanne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meindl, Alfons | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Miao, Hui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Muir, Kenneth | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Neuhausen, Susan L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nevanlinna, Heli | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Neven, Patrick | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Olson, Janet E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Perkins, Barbara | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peterlongo, Paolo | UNSPECIFIED | orcid.org/0000-0001-6951-6855 | UNSPECIFIED | Phillips, Kelly-Anne | UNSPECIFIED | orcid.org/0000-0002-0475-1771 | UNSPECIFIED | Pylkas, Katri | UNSPECIFIED | orcid.org/0000-0002-2449-0521 | UNSPECIFIED | Rudolph, Anja | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Santella, Regina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sawyer, Elinor J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schmutzler, Rita K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schoemaker, Minouk | UNSPECIFIED | orcid.org/0000-0001-8403-2234 | UNSPECIFIED | Shah, Mitul | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Shrubsole, Martha | UNSPECIFIED | orcid.org/0000-0002-5591-7575 | UNSPECIFIED | Southey, Melissa C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Swerdlow, Anthony J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Toland, Amanda E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Tomlinson, Ian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Torres, Diana | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ursin, Giske | UNSPECIFIED | orcid.org/0000-0002-0835-9507 | UNSPECIFIED | Van Der Luijt, Rob B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Verhoef, Senno | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wang-Gohrke, Shan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Whittemore, Alice S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Winqvist, Robert | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zamora, M. Pilar | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zhao, Hui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Dunning, Alison M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simard, Jacques | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hall, Per | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kraft, Peter | UNSPECIFIED | orcid.org/0000-0002-4472-8103 | UNSPECIFIED | Pharoah, Paul | UNSPECIFIED | orcid.org/0000-0001-8494-732X | UNSPECIFIED | Hunter, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Easton, Douglas F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zheng, Wei | UNSPECIFIED | orcid.org/0000-0003-1226-070X | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-277512 |
DOI: |
10.1007/s10552-016-0741-6 |
Journal or Publication Title: |
Cancer Causes Control |
Volume: |
27 |
Number: |
5 |
Page Range: |
S. 679 - 694 |
Date: |
2016 |
Publisher: |
SPRINGER |
Place of Publication: |
DORDRECHT |
ISSN: |
1573-7225 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
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GENOME-WIDE ASSOCIATION; POPULATION-BASED COHORT; MULTIETHNIC COHORT; CONSENSUS REPORT; LOCI; MELLITUS; METAANALYSIS; OBESITY; PAGE | Multiple languages | Oncology; Public, Environmental & Occupational Health | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/27751 |
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