Universität zu Köln

Hagmeyer, Lars, Priegnitz, Christina, Kocher, Martin, Schilcher, Burkhart, Budach, Wilfried, Treml, Marcel, Stieglitz, Sven and Randerath, Winfried (2016). Fiducial marker placement via conventional or electromagnetic navigation bronchoscopy (ENB): an interdisciplinary approach to the curative management of lung cancer. Clin. Respir. J., 10 (3). S. 291 - 298. HOBOKEN: WILEY. ISSN 1752-699X

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Abstract

Background and AimsConventional and electromagnetic navigation bronchoscopy (ENB) is generally used as a diagnostic tool in suspicious pulmonary nodules. The use of this technique for the placement of fiducial markers in patients with inoperable but early-stage lung cancer could present an innovative approach enabling risk-reduced therapy. MethodsWe present seven clinical cases where conventional bronchoscopy and ENB were used as part of an experimental interdisciplinary approach to clinical management and therapy planning. In each case, we analyzed the clinical indication, endoscopic procedures and post-interventional outcome. ResultsIn six patients (three females, three males) with peripheral non-small cell lung cancer (NSCLC), stage cT1cN0cM0, surgery and conventional stereotactic radiation therapy was not possible because of end-stage chronic obstructive pulmonary disease. ENB was used for fiducial marker placement prior to cyberknife radiotherapy. No procedure-related complications were observed. Complete remission could be achieved in four cases, partial remission in two cases and no relevant complications induced by radiotherapy were observed. In one male patient, an endoluminal relapse in the right lower lobe was diagnosed following a right upper lobe resection for a NSCLC. The tumor could not be clearly identified by computerized tomography, so that the bronchoscopic placement of a fiducial marker in the tumor was performed in order to allow stereotactic radiochemotherapy, by which complete remission could be achieved. ConclusionFiducial marker placement may be an interesting bronchoscopic technique in the interdisciplinary therapeutic approach to inoperable early-stage lung cancer. In the described cases, therapy planning was successful and no procedure-related complications were observed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hagmeyer, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Priegnitz, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kocher, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilcher, Burkhart UNSPECIFIED UNSPECIFIED UNSPECIFIED Budach, Wilfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Treml, Marcel UNSPECIFIED UNSPECIFIED UNSPECIFIED Stieglitz, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, Winfried UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277530
DOI:	10.1111/crj.12214
Journal or Publication Title:	Clin. Respir. J.
Volume:	10
Number:	3
Page Range:	S. 291 - 298
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1752-699X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-TRACKING; STEREOTACTIC RADIOSURGERY; CYBERKNIFE RADIOSURGERY; COMPUTED-TOMOGRAPHY; SPIRAL CT; RADIOTHERAPY; MOTION Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27753