Universität zu Köln

Vossel, Simone ORCID: 0000-0002-6351-8849 and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2016). Contralesional distractors enhance ipsilesional target processing after right-hemispheric stroke. Cortex, 78. S. 115 - 125. PARIS: ELSEVIER MASSON, CORPORATION OFFICE. ISSN 1973-8102

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Abstract

Stroke can result in marked impairments in the processing of information presented in contralesional space. The present prospective study investigated how a contralesional distractor affects ipsilesional perception in patients with a right-hemispheric stroke. In a simple target detection task, the influence of the distractor on reaction times (RTs) was examined in stroke patients and compared to the performance of healthy elderly controls. Distractor interference effects were related to measures of neglect and extinction using a regression analysis. Moreover, the magnitude of the behavioural distractor effect entered a voxel-based lesion-symptom mapping (VLSM) analysis with the hypothesis that parietal and temporoparietal lesions are related to altered distractor processing. While the presence of a distractor in the opposite hemifield slowed down RTs in healthy controls for left and right targets, this effect was only observed for contralesional left targets in the group of right hemispheric patients. In stark contrast, the presence of a distractor in the contralesional hemifield expedited ipsilesional (i.e., right) target detection. This effect was significantly related to lesions in the anterior middle temporal and temporoparietal cortex, external and internal capsule, as well as the superior longitudinal fascicle (SLF). These results elucidate the nature of the disruption of attentive processing in the contralesional hemifield after right hemispheric stroke. More specifically, they shed light on the abnormal prioritisation of ipsilesional information: our data suggest that damage to the temporal and temporoparietal cortex and white matter tracts may transform contralesional stimulation into an unspecific saliency signal contributing to facilitated information processing in ipsilesional space. (C) 2016 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vossel, Simone UNSPECIFIED orcid.org/0000-0002-6351-8849 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-277553
DOI:	10.1016/j.cortex.2016.02.010
Journal or Publication Title:	Cortex
Volume:	78
Page Range:	S. 115 - 125
Date:	2016
Publisher:	ELSEVIER MASSON, CORPORATION OFFICE
Place of Publication:	PARIS
ISSN:	1973-8102
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEMISPATIAL NEGLECT; UNILATERAL NEGLECT; SPATIAL ATTENTION; LESION; DEFICITS; MECHANISMS; JUNCTION; STIMULI Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27755