Guaras, Adela, Perales-Clemente, Ester, Calvo, Enrique, Acin-Perez, Rebeca ORCID: 0000-0001-9553-8337, Loureiro-Lopez, Marta, Pujol, Claire, Martinez-Carrascoso, Isabel, Nunez, Estefania ORCID: 0000-0002-0876-1264, Garcia-Marques, Fernando ORCID: 0000-0002-2105-2905, Angeles Rodriguez-Hernandez, Maria, Cortes, Ana, Diaz, Francisca, Perez-Martos, Acisclo, Moraes, Carlos T., Fernandez-Silva, Patricio, Trifunovic, Aleksandra, Navas, Placido, Vazquez, Jesus ORCID: 0000-0003-1461-5092 and Enriquez, Jose A. (2016). The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency. Cell Reports, 15 (1). S. 197 - 210. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

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Abstract

Electrons feed into the mitochondrial electron transport chain (mETC) from NAD-or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To prevent this, the mETC superstructure can be reconfigured through the degradation of respiratory complex I, liberating associated complex III to increase electron flux via FAD at the expense of NAD. Here, we demonstrate that this adaptation is driven by the ratio of reduced to oxidized CoQ. Saturation of CoQ oxidation capacity induces reverse electron transport from reduced CoQ to complex I, and the resulting local generation of superoxide oxidizes specific complex I proteins, triggering their degradation and the disintegration of the complex. Thus, CoQ redox status acts as a metabolic sensor that fine-tunes mETC configuration in order to match the prevailing substrate profile.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Guaras, AdelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perales-Clemente, EsterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calvo, EnriqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Acin-Perez, RebecaUNSPECIFIEDorcid.org/0000-0001-9553-8337UNSPECIFIED
Loureiro-Lopez, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pujol, ClaireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Carrascoso, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunez, EstefaniaUNSPECIFIEDorcid.org/0000-0002-0876-1264UNSPECIFIED
Garcia-Marques, FernandoUNSPECIFIEDorcid.org/0000-0002-2105-2905UNSPECIFIED
Angeles Rodriguez-Hernandez, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cortes, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz, FranciscaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Martos, AciscloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moraes, Carlos T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Silva, PatricioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trifunovic, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navas, PlacidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vazquez, JesusUNSPECIFIEDorcid.org/0000-0003-1461-5092UNSPECIFIED
Enriquez, Jose A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-278873
DOI: 10.1016/j.celrep.2016.03.009
Journal or Publication Title: Cell Reports
Volume: 15
Number: 1
Page Range: S. 197 - 210
Date: 2016
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 2211-1247
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CYTOCHROME-C-OXIDASE; COMPLEX-I; ELECTRON-TRANSPORT; SUPRAMOLECULAR ORGANIZATION; MITOCHONDRIAL-DNA; ASSEMBLY/STABILITY; SUPERCOMPLEXES; IDENTIFICATION; INTEGRATION; EXPRESSIONMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/27887

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