Universität zu Köln

von Laffert, M., Schirmacher, P., Warth, A., Weichert, W., Buettner, R., Huber, R. M., Wolf, J., Griesinger, F., Dietel, M. and Grohe, Ch. (2016). ALK-Diagnostics in non-small cell Lung Cancer (NSCLC) - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)? Statement of the German Society for Pathology and the WG Thoracic Oncology of the Working Group Oncology/German Cancer Society e.V. Pneumologie, 70 (4). S. 277 - 282. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8790

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Abstract

The EML4-ALK pathway plays an important role in a significant subset of non-small cell lung cancer patients. Treatment options such as tyrosine kinase inhibitors directed against the EML4-ALK signalling pathway lead to improved progression free and overall survival. These therapeutic options are chosen on the basis of the identification of the underlying genetic signature of the EMLALK translocation. Efficient and easily accessible testing tools are required to identify the patients in time. While FISH techniques have been implemented to characterize this translocation for some time, the implementation of this testing is hampered by its broad use of resources. Immunohistochemical techniques to identify and screen for EML4-ALK translocations may play an important role in the near future. This consensus paper offers recommendations of the sequence and quality of the respective test approaches which are validated on the basis of the current literature.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Laffert, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirmacher, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Warth, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weichert, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huber, R. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Griesinger, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grohe, Ch. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-279819
DOI:	10.1055/s-0042-102626
Journal or Publication Title:	Pneumologie
Volume:	70
Number:	4
Page Range:	S. 277 - 282
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-8790
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANAPLASTIC LYMPHOMA KINASE; GENE REARRANGEMENT; CARCINOMAS; CRIZOTINIB; ADENOCARCINOMAS; HETEROGENEITY Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/27981