Universität zu Köln

Doetsch, Joerg, Alejandre-Alcazar, Miguel, Janoschek, Ruth, Nuesken, Eva, Weber, Lutz T. and Nuesken, Kai D. (2016). Perinatal programming of renal function. CURR. OPIN. PEDIATR., 28 (2). S. 188 - 195. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1531-698X

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Abstract

Purpose of reviewPerinatal programming of renal function reflects the epigenetic alteration of genetically determined development by environmental factors. These include intrauterine malnutrition, pre and postnatal overnutrition, glucocorticoids, and certain toxins such as smoking. This review aims to summarize the most important findings.Recent findingsHuman studies may show an increased susceptibility toward the general prevalence of renal failure in already small for gestational age children and adolescents. In particular, glomerular diseases present with a more severe clinical course. Partially related, partially independently, arterial hypertension is found in this at-risk group. The findings can mostly be confirmed in animal models. Both intrauterine nutrient deprived and overfed rodents show a tendency toward developing glomerulosclerosis and other renal disorders. Animal studies attempt to imitate clinical conditions, however, there are difficulties in transferring the findings to the human setting. The reduction of nephron number, especially in intrauterine growth-restricted humans and animals, is one mechanism of perinatal programming in the kidneys. In addition, vascular and endocrine alterations are prevalent. The molecular changes behind these mechanisms include epigenetic changes such as DNA-methylation, microRNAs, and histone modifications.SummaryFuture research will have to establish clinical studies with clear and well defined inclusion criteria which also reflect prenatal life. The use of transgenic animal models might help to obtain a deeper insight into the underlying mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doetsch, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Alejandre-Alcazar, Miguel UNSPECIFIED UNSPECIFIED UNSPECIFIED Janoschek, Ruth UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Lutz T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuesken, Kai D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-280257
DOI:	10.1097/MOP.0000000000000312
Journal or Publication Title:	CURR. OPIN. PEDIATR.
Volume:	28
Number:	2
Page Range:	S. 188 - 195
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1531-698X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTRAUTERINE GROWTH RESTRICTION; FOR-GESTATIONAL-AGE; LOW-BIRTH-WEIGHT; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; MATERNAL PROTEIN RESTRICTION; RENIN-ANGIOTENSIN SYSTEM; REDUCES NEPHRON NUMBER; BLOOD-PRESSURE; GENE-EXPRESSION; IN-UTERO Multiple languages Pediatrics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28025