Universität zu Köln

Taeger, Dirk ORCID: 0000-0002-5340-5584, McCunney, Robert, Bailer, Ursula, Barthel, Kai, Kuepper, Ulrich, Bruening, Thomas, Morfeld, Peter and Merget, Rolf (2016). Cross-Sectional Study on Nonmalignant Respiratory Morbidity due to Exposure to Synthetic Amorphous Silica. J. Occup. Environ. Med., 58 (4). S. 376 - 385. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5948

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Abstract

Objectives: The aim of this study was to assess the health impact of chronic exposure to synthetic amorphous silica (SAS) on nonmalignant respiratory morbidity. Methods: We used multiple linear and logistic regression models and Monte Carlo multimodel analyses of two exposure scenarios to evaluate the effect of cumulative exposure to inhalable SAS dust on symptoms, spirometry, and chest films in 462 male workers from five German SAS-producing plants. Results: Exposure to SAS was associated with a reduction in forced vital capacity (FVC) in one of the two exposure scenarios but had no effect on forced expiratory volume in 1 second (FEV1) or FEV1/FVC in either exposure scenario. Monte Carlo analysis indicated a decline in FVC of -11mL per 10 mg/m(3)-years exposure (-6 to -0.4). Chest films showed no evidence of pneumoconiosis. Conclusion: This study provides limited evidence of minor dose-related effects of chronic exposure to SAS on lung function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Taeger, Dirk UNSPECIFIED orcid.org/0000-0002-5340-5584 UNSPECIFIED McCunney, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Bailer, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Barthel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuepper, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Merget, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-280549
DOI:	10.1097/JOM.0000000000000666
Journal or Publication Title:	J. Occup. Environ. Med.
Volume:	58
Number:	4
Page Range:	S. 376 - 385
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-5948
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LUNG-FUNCTION; INHALATION EXPOSURE; RESPONSE ANALYSES; PULMONARY; CRYSTALLINE; DECLINE; WORKERS; CANCER; AGE Multiple languages Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28054