Universität zu Köln

Howe, Kerstin ORCID: 0000-0003-2237-513X, Schiffer, Philipp H., Zielinski, Julia, Wiehe, Thomas ORCID: 0000-0002-8932-2772, Laird, Gavin K., Marioni, John C., Soylemez, Onuralp, Kondrashov, Fyodor and Leptin, Maria ORCID: 0000-0001-7097-348X (2016). Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Open Biol, 6 (4). LONDON: ROYAL SOC. ISSN 2046-2441

Full text not available from this repository.

Abstract

Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins. Mammals have small numbers of NLR proteins, whereas in some species, mostly those without adaptive immune systems, NLRs have expanded into very large families. We describe a family of nearly 400 NLR proteins encoded in the zebrafish genome. The proteins share a defining overall structure, which arose in fishes after a fusion of the core NLR domains with a B30.2 domain, but can be subdivided into four groups based on their NACHT domains. Gene conversion acting differentially on the NACHT and B30.2 domains has shaped the family and created the groups. Evidence of positive selection in the B30.2 domain indicates that this domain rather than the leucine-rich repeats acts as the pathogen recognition module. In an unusual chromosomal organization, the majority of the genes are located on one chromosome arm, interspersed with other large multigene families, including a new family encoding zinc-finger proteins. The NLR-B30.2 proteins represent a new family with diversity in the specific recognition module that is present in fishes in spite of the parallel existence of an adaptive immune system.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Howe, Kerstin UNSPECIFIED orcid.org/0000-0003-2237-513X UNSPECIFIED Schiffer, Philipp H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zielinski, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiehe, Thomas UNSPECIFIED orcid.org/0000-0002-8932-2772 UNSPECIFIED Laird, Gavin K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marioni, John C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Soylemez, Onuralp UNSPECIFIED UNSPECIFIED UNSPECIFIED Kondrashov, Fyodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-280688
DOI:	10.1098/rsob.160009
Journal or Publication Title:	Open Biol
Volume:	6
Number:	4
Date:	2016
Publisher:	ROYAL SOC
Place of Publication:	LONDON
ISSN:	2046-2441
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATHOGEN RECOGNITION; GENE CONVERSION; INNATE IMMUNITY; GENOMIC ANALYSIS; TELEOST FISH; DANIO-RERIO; SEQUENCE; COMPLEXITY; MODELS; DUPLICATION Multiple languages Biochemistry & Molecular Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28068