Universität zu Köln

Schick, Tina, Ersoy, Lebriz, Lechanteur, Yara T. E., Saksens, Nicole T. M., Hoyng, Carel B., Den Hollander, Anneke I., Kirchhof, Bernd and Fauser, Sascha (2016). HISTORY OF SUNLIGHT EXPOSURE IS A RISK FACTOR FOR AGE-RELATED MACULAR DEGENERATION. Retin.-J. Retin. Vitr. Dis., 36 (4). S. 787 - 791. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose:To evaluate effects of current and past sunlight exposure and iris color on early and late age-related macular degeneration (AMD).Methods:Of 3,701 individuals from the EUGENDA database, 752 (20.3%) showed early AMD, 1,179 (31.9%) late AMD, and 1,770 (47.8%) were controls. Information about current and past sunlight exposure, former occupation type, subdivided in indoor working and outdoor working, and iris color were obtained by standardized interviewer-assisted questionnaires. Associations between environmental factors adjusted for age, gender, and smoking and early and late AMD were performed by multivariate regression analysis.Results:Current sunlight exposure showed no association with early AMD or late AMD, but past sunlight exposure (8 hours outside daily) was significantly associated with early AMD (odds ratio: 5.54, 95% confidence interval 1.25-24.58, P = 0.02) and late AMD (odds ratio: 2.77, 95% confidence interval 1.25-6.16, P = 0.01). Outside working was found to be associated with late AMD (odds ratio: 2.57, 95% confidence interval 1.89-3.48, P = 1.58 x 10(-9)). No association was observed between iris color and early or late AMD.Conclusion:Sunlight exposure during working life is an important risk factor for AMD, whereas sunlight exposure after retirement seems to have less influence on the disease development. Therefore, preventive measures, for example, wearing sunglasses to minimize sunlight exposure, should start early to prevent development of AMD later in life.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schick, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ersoy, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Lechanteur, Yara T. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Saksens, Nicole T. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Den Hollander, Anneke I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhof, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-280733
DOI:	10.1097/IAE.0000000000000756
Journal or Publication Title:	Retin.-J. Retin. Vitr. Dis.
Volume:	36
Number:	4
Page Range:	S. 787 - 791
Date:	2016
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1539-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BEAVER DAM EYE; SKIN SUN SENSITIVITY; BLUE MOUNTAINS EYE; 10-YEAR INCIDENCE; CATARACT-SURGERY; IRIS COLOR; 5-YEAR INCIDENCE; LATE-STAGE; MACULOPATHY; POPULATION Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28073