Universität zu Köln

Pixberg, Caroline, Koch, Raphael, Eich, Hans Theodor, Martinsson, Ulla, Kristensen, Ingrid, Matuschek, Christiane, Kortmann, Rolf-Dieter, Pohl, Fabian, Elsayad, Khaled, Christiansen, Hans, Willich, Normann, Lindh, Jack and Steinmann, Diana (2016). Acute Toxicity Grade 3 and 4 After Irradiation in Children and Adolescents: Results From the IPPARCA Collaboration. Int. J. Radiat. Oncol. Biol. Phys., 94 (4). S. 792 - 800. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-355X

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Abstract

Purpose: In the context of oncologic therapy for children, radiation therapy is frequently indicated. This study identified the frequency of and reasons for the development of high-grade acute toxicity and possible sequelae. Materials and Methods: Irradiated children have been prospectively documented since 2001 in the Registry for the Evaluation of Side Effects After Radiation in Childhood and Adolescence (RiSK) database in Germany and since 2008 in the registry for radiation therapy toxicity (RADTOX) in Sweden. Data were collected using standardized, published forms. Toxicity classification was based on Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: As of June 2013, 1500 children have been recruited into the RiSK database and 485 into the RADTOX registry leading to an analysis population of 1359 patients (age range 0-18). A total of 18.9% (n=257) of all investigated patients developed high-grade acute toxicity (grades 3/4). High-grade toxicity of the bone marrow was documented for 63.8% (n=201) of those patients, oral mucositis for 7.6% (n=24), and dermatitis for 7.6% (n=24). Patients with high-grade acute toxicity received concomitant chemotherapy more frequently (56%) than patients with no or lower acute toxicity (31.5%). In multivariate analyses, concomitant chemotherapy, diagnosis of Ewing sarcoma, and total radiation dose showed a statistically noticeable effect (P <=.05) on acute toxicity, whereas age, concomitant chemotherapy, Hodgkin lymphoma, Ewing sarcoma, total radiation dose, and acute toxicity influenced the time until maximal late toxicity. Conclusions: Generally, high-grade acute toxicity after irradiation in children and adolescence occurs in a moderate proportion of patients (18.9%). As anticipated, the probability of acute toxicity appeared to depend on the prescribed dose as well as concomitant chemotherapy. The occurrence of chronic toxicity correlates with the prior acute toxicity grade. Age seems to influence the time until maximal late toxicity but not the development of acute toxicity. (c) 2016 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pixberg, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Raphael UNSPECIFIED UNSPECIFIED UNSPECIFIED Eich, Hans Theodor UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinsson, Ulla UNSPECIFIED UNSPECIFIED UNSPECIFIED Kristensen, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Matuschek, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Kortmann, Rolf-Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohl, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Elsayad, Khaled UNSPECIFIED UNSPECIFIED UNSPECIFIED Christiansen, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Willich, Normann UNSPECIFIED UNSPECIFIED UNSPECIFIED Lindh, Jack UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinmann, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-281372
DOI:	10.1016/j.ijrobp.2015.12.353
Journal or Publication Title:	Int. J. Radiat. Oncol. Biol. Phys.
Volume:	94
Number:	4
Page Range:	S. 792 - 800
Date:	2016
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-355X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RADIATION-THERAPY; CHILDHOOD-CANCER; RADIOTHERAPY; SURVIVORS; RISK; ASSOCIATION Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28137