Universität zu Köln

Carrion, Daniela Calderon, Korkmaz, Yuksel, Cho, Britta, Kopp, Marion, Bloch, Wilhelm, Addicks, Klaus and Niedermeier, Wilhelm (2016). Loss of A beta-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis. Int. J. Oral Sci., 8 (1). S. 32 - 39. LONDON: NATURE PUBLISHING GROUP. ISSN 2049-3169

Full text not available from this repository.

Abstract

The Merkel cell-neurite complex initiates the perception of touch and mediates A beta slowly adapting type I responses. Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation, whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa. To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex, healthy oral mucosa! epithelium and lesional oral mucosa! epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry (the avidin-biotin-peroxidase complex and double immunofluorescence methods) using pan cytokeratin, cytokeratin 20 (K20, a Merkel cell marker), and neurofilament 200 (NF200, a myelinated A beta- and A delta-nerve fibre marker) antibodies. NF200-immunoreactive (ir) nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed. In the healthy oral mucosa, K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected. In the lesional oral mucosa of lichen planus and hyperkeratosis patients, extremely rare NF200-ir nerve fibres were detected only in the lamina propria. Compared with healthy tissues, lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium. Lichen planus and hyperkeratosis were associated with the absence of A beta-nerve endings in the oral mucosal epithelium. Thus, we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosa! epithelium is impaired in lichen planus and hyperkeratosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Carrion, Daniela Calderon UNSPECIFIED UNSPECIFIED UNSPECIFIED Korkmaz, Yuksel UNSPECIFIED UNSPECIFIED UNSPECIFIED Cho, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopp, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Niedermeier, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-282065
DOI:	10.1038/ijos.2015.31
Journal or Publication Title:	Int. J. Oral Sci.
Volume:	8
Number:	1
Page Range:	S. 32 - 39
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2049-3169
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SKIN; TRANSDUCTION; MODULATION; MECHANISMS; RECEPTORS; FIBERS Multiple languages Dentistry, Oral Surgery & Medicine Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28206