Universität zu Köln

Morfeld, Peter, Mundt, Kenneth A., Dell, Linda D., Sorahan, Tom ORCID: 0000-0003-4904-4496 and McCunney, Robert J. (2016). Meta-Analysis of Cardiac Mortality in Three Cohorts of Carbon Black Production Workers. Int. J. Environ. Res. Public Health, 13 (3). BASEL: MDPI. ISSN 1660-4601

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Abstract

Epidemiological studies have demonstrated associations between airborne environmental particle exposure and cardiac disease and mortality; however, few have examined such effects from poorly soluble particles of low toxicity such as manufactured carbon black (CB) particles in the work place. We combined standardised mortality ratio (SMR) and Cox proportional hazards results from cohort studies of US, UK and German CB production workers. Under a common protocol, we analysed mortality from all causes, heart disease (HD), ischemic heart disease (IHD) and acute myocardial infarction (AMI). Fixed and random effects (RE) meta-regression models were fit for employment duration, and for overall cumulative and lugged quantitative CB exposure estimates. Full cohort meta-SMRs (RE) were 1.01 (95% confidence interval (CI) 0.79-1.29) for HD; 1.02 (95% CI 0.80-1.30) for IHD, and 1.08 (95% CI 0.74-1.59) for AMI mortality. For all three outcomes, meta-SMRs were heterogeneous, increased with time since first and time since last exposure, and peaked after 25-29 or 10-14 years, respectively. Meta-Cox coefficients showed no association with lugged duration of exposure. A small but imprecise increased AMI mortality risk was suggested for cumulative exposure (RE-hazards ratio (HR) = 1.10 per 100 mg/m(3)-years; 95% CI 0.92-1.31), but not for lugged exposures. Our results do not demonstrate that airborne CB exposure increases all-cause or cardiac disease mortality.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mundt, Kenneth A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dell, Linda D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorahan, Tom UNSPECIFIED orcid.org/0000-0003-4904-4496 UNSPECIFIED McCunney, Robert J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-282397
DOI:	10.3390/ijerph13030302
Journal or Publication Title:	Int. J. Environ. Res. Public Health
Volume:	13
Number:	3
Date:	2016
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1660-4601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ISCHEMIC-HEART-DISEASE; LONG-TERM EXPOSURE; LUNG-CANCER MORTALITY; PARTICULATE AIR-POLLUTION; ROAD TRAFFIC NOISE; OCCUPATIONAL-EXPOSURE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; RESPIRATORY-DISEASE; PARTICLE INHALATION Multiple languages Environmental Sciences; Public, Environmental & Occupational Health Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28239