Universität zu Köln

Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Shao, Junming, Meng, Chun, Grimmer, Timo, Diehl-Schmid, Janine ORCID: 0000-0002-7745-1382, Yousefi, Behrooz H., Foerster, Stefan, Riedl, Valentin ORCID: 0000-0002-2861-8449, Drzezga, Alexander and Sorg, Christian (2016). Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study. J. Nucl. Med., 57 (3). S. 410 - 416. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

The network degeneration hypothesis (NDH) of neurodegenerative syndromes suggests that pathologic brain changes distribute primarily along distinct brain networks, which are characteristic for different syndromes. Brain changes of neurodegenerative syndromes can be characterized in vivo by different imaging modalities. Our aim was to test the hypothesis whether multimodal imaging based on the NDH separates individual patients with different neurodegenerative syndromes. Methods: Twenty patients with Alzheimer disease (AD) and 20 patients with frontotemporal lobar degeneration (behavioral variant frontotemporal dementia [bvFTD, n = 11], semantic dementia [SD, n = 4], or progressive nonfluent aphasia [PNFA, n = 5]) underwent simultaneous MRI and F-18-FDG PET in a hybrid PET/MR scanner. The 3 outcome measures were voxelwise values of degree centrality as a surrogate for regional functional connectivity, glucose metabolism as a surrogate for regional metabolism, and volumetric-based morphometry as a surrogate for regional gray matter volume. Outcome measures were derived from predefined core regions of 4 intrinsic networks based on the NDH, which have been demonstrated to be characteristic for AD, bvFTD, SD, and PNFA, respectively. Subsequently, we applied support vector machine to classify individual patients via combined imaging measures, and results were evaluated by leave-one-out cross-validation. Results: On the basis of multimodal voxelwise regional patterns, classification accuracies for separating patients with different neurodegenerative syndromes were 77.5% for AD versus others, 82.5% for bvFTD versus others, 97.5% for SD versus others, and 87.5% for PNFA versus others. Multimodal classification results were significantly superior to unimodal approaches. Conclusion: Our finding provides initial evidence that the combination of regional metabolism, functional connectivity, and gray matter volume, which were derived from disease characteristic networks, separates individual patients with different neurodegenerative syndromes. Preliminary results suggest that employing multimodal imaging guided by the NDH may generate promising biomarkers of neurodegenerative syndromes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED Shao, Junming UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Chun UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl-Schmid, Janine UNSPECIFIED orcid.org/0000-0002-7745-1382 UNSPECIFIED Yousefi, Behrooz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283249
DOI:	10.2967/jnumed.115.165464
Journal or Publication Title:	J. Nucl. Med.
Volume:	57
Number:	3
Page Range:	S. 410 - 416
Date:	2016
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FRONTOTEMPORAL LOBAR DEGENERATION; ALZHEIMERS-DISEASE; HUMAN BRAIN; SEMANTIC DEMENTIA; AMYLOID-BETA; FDG-PET; CONNECTIVITY; MRI; ATROPHY; HYPOMETABOLISM Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28324