Universität zu Köln

Sterner-Kock, Anja, Haider, Wolfram, Sacchini, Flavio ORCID: 0000-0003-2618-6192, Liljander, Anne, Meens, Jochen, Poole, Jane, Guschlbauer, Maria ORCID: 0000-0002-5401-4542, Heller, Martin, Naessens, Jan and Jores, Joerg ORCID: 0000-0003-3790-5746 (2016). Morphological characterization and immunohistochemical detection of the proinflammatory cytokines IL-1 beta, IL-17A, and TNF-alpha in lung lesions associated with contagious bovine pleuropneumonia. Trop. Anim. Health Prod., 48 (3). S. 569 - 577. DORDRECHT: SPRINGER. ISSN 1573-7438

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Abstract

Contagious bovine pleuropneumonia (CBPP), a severe respiratory disease, is characterized by massive inflammation of the lung especially during the acute clinical stage of infection. Tissue samples from cattle, experimentally infected with Mycoplasma mycoides subsp. mycoides Afad,, were subjected to histopathological and immunohistochemical examination in order to provide insight into innate immune pathways that shape inflammatory host responses. Lung lesions were characterized by vasculitis, necrosis, and increased presence of macrophages and neutrophils, relative to uninfected animals. The presence of three cytokines associated with innate inflammatory immune responses, namely, IL-1 beta, IL-17A, and TNF-alpha, were qualitatively investigated in situ. Higher cytokine levels were detected in lung tissue samples from CBPP-affected cattle compared to samples derived from an uninfected control group. We therefore conclude that the cytokines TNF-alpha and IL-1 beta, which are prevalent in the acute phase of infections, play a role in the inflammatory response seen in the lung tissue in CBPP. IL-17A gets released by activated macrophages and attracts granulocytes that modulate the acute phase of the CBPP lesions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sterner-Kock, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Haider, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Sacchini, Flavio UNSPECIFIED orcid.org/0000-0003-2618-6192 UNSPECIFIED Liljander, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Meens, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Poole, Jane UNSPECIFIED UNSPECIFIED UNSPECIFIED Guschlbauer, Maria UNSPECIFIED orcid.org/0000-0002-5401-4542 UNSPECIFIED Heller, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Naessens, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jores, Joerg UNSPECIFIED orcid.org/0000-0003-3790-5746 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283283
DOI:	10.1007/s11250-016-0994-9
Journal or Publication Title:	Trop. Anim. Health Prod.
Volume:	48
Number:	3
Page Range:	S. 569 - 577
Date:	2016
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-7438
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYCOIDES SUBSP MYCOIDES; CATTLE; INFECTION; CELLS; GAMMA; RESPONSES; CBPP Multiple languages Agriculture, Dairy & Animal Science; Veterinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28328