Universität zu Köln

Wang, Li, Lv, Meili, Zaumsegel, Daniel, Zhang, Lushun, Liu, Fengji, Xiang, Jihua, Li, Jun, Schneider, Peter M. ORCID: 0000-0003-0744-2349, Liang, Weibo and Zhang, Lin (2016). A comparative study of insertion/deletion polymorphisms applied among Southwest, South and Northwest Chinese populations using Investigator (R) DIPplex. Forensic Sci. Int.-Genet., 21. S. 10 - 15. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-0326

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Abstract

The low mutation rates, short amplicon sizes and length variation characteristics of biallelic insertion/deletion polymorphisms (INDELs) are features that allow combining advantages of both STR and SNP markers for genetic analysis. The Qiagen Investigator DIPplex kit contains 30 biallelic autosomal INDELs plus Amelogenin for forensic personal identification and parentage testing. This study compares general performances, forensic and population data collected in 7 Chinese ethnic populations (Han, Tibetan, Yi, Zhuang, Dong, Miao and Uyghur) from three areas (Southwest, South and Northwest) of China by DIPplex kit. There were no significant departures from Hardy-Weinberg equilibrium (HWE) of the 30 markers in all the tested populations after Bonferroni correction. The combined matching probabilities ranged from 1.4273 x 10(-10) for the Dong minority to 1.2817 x 10(-12) for the Uyghur minority. The combined power of paternity exclusion was from 0.9854 to 0.9968. All pairwise genetic differences (F-ST) between the seven ethnic groups were less than 0.05, and the results of STRUCTURE analysis did not indicate the presence of substructures suggesting genetic similarity among the populations in these three areas. The DIPplex kit can be used as a good additional tool for forensic personal identification in these three areas of China. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED Lv, Meili UNSPECIFIED UNSPECIFIED UNSPECIFIED Zaumsegel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Lushun UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Fengji UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiang, Jihua UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Jun UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Peter M. UNSPECIFIED orcid.org/0000-0003-0744-2349 UNSPECIFIED Liang, Weibo UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Lin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283318
DOI:	10.1016/j.fsigen.2015.08.005
Journal or Publication Title:	Forensic Sci. Int.-Genet.
Volume:	21
Page Range:	S. 10 - 15
Date:	2016
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	1878-0326
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELETION POLYMORPHISMS; GENETIC-ANALYSIS; INDEL MARKERS; FORENSIC USE; MULTIPLEX; ASSAY; LOCI; KIT Multiple languages Genetics & Heredity; Medicine, Legal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28331