Universität zu Köln

Haupt, Walter F., Chopan, Ghesal, Sobesky, Jan, Liu, Wei-Chi and Dohmen, Christian (2016). Prognostic value of somatosensory evoked potentials, neuron-specific enolase, and S100 for short-term outcome in ischemic stroke. J. Neurophysiol., 115 (3). S. 1273 - 1279. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1598

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Abstract

To predict short-term outcome in acute ischemic stroke, we analyzed somatosensory evoked potentials (SEP) and biochemical parameters [neuron-specific enolase (NSE) and S100 protein] in a prospective study with serial measurement. In 31 patients with 1st middle cerebral artery infarction, serum NSE and S100 protein were measured daily between days 1 and 6 poststroke. The N20 and N70 components of the SEP (SEP20 and SEP70) were determined on days 1 and 6. SEP and biochemical markers in stroke patients were compared with a control group. Short-term outcome was assessed by the modified Rankin Scale (mRS) at days 7-10 and was dichotomized between good (mRS 0-2) and poor (mRS >= 3) outcome. Specificity and positive predictive value (PPV) were high at day 1 for SEP (SEP20: 100% for both; SEP70: 93 and 88%, respectively) compared with lower values for NSE (67 and 50%) and S100 (23 and 57%). In contrast, S100 showed the highest sensitivity at day 1 with 77% compared with a relatively low sensitivity of NSE (31%) and SEP (SEP20: 35%, SEP70: 47%). The biochemical markers showed an improving sensitivity over time with best values (>90%) between days 3 and 4 at the expense of a lower specificity. Specificity and PPV of SEP on day 6 was still 100% with sensitivity increasing up to 53% (SEP20) and 60% (SEP70). SEP could early differentiate between good and poor outcome and reliably predict poor outcome. Since biochemical markers and SEP complement each other in the prognosis of stroke, a combined application of these markers seems promising.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haupt, Walter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chopan, Ghesal UNSPECIFIED UNSPECIFIED UNSPECIFIED Sobesky, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Wei-Chi UNSPECIFIED UNSPECIFIED UNSPECIFIED Dohmen, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-283853
DOI:	10.1152/jn.01012.2015
Journal or Publication Title:	J. Neurophysiol.
Volume:	115
Number:	3
Page Range:	S. 1273 - 1279
Date:	2016
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRITICAL-CARE PATIENTS; NEUROBIOCHEMICAL MARKERS; INFARCT VOLUME; S-100 PROTEIN; DAMAGE Multiple languages Neurosciences; Physiology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/28385