Gansevoort, Ron T., Arici, Mustafa, Benzing, Thomas, Birn, Henrik ORCID: 0000-0003-3715-7266, Capasso, Giovambattista ORCID: 0000-0003-3469-8614, Covic, Adrian ORCID: 0000-0002-9985-2486, Devuyst, Olivier, Drechsler, Christiane, Eckardt, Kai-Uwe, Emma, Francesco, Knebelmann, Bertrand, Le Meur, Yannick ORCID: 0000-0001-8913-415X, Massy, Ziad A., Ong, Albert C. M., Ortiz, Alberto, Schaefer, Franz, Torra, Roser ORCID: 0000-0001-8714-2332, Vanholder, Raymond, Wiecek, Andrzej, Zoccali, Carmine and Van Biesen, Wim (2016). Recommendations for the use of tolvaptan in autosomal dominant polycystic kidney disease: a position statement on behalf of the ERA-EDTA Working Groups on Inherited Kidney Disorders and European Renal Best Practice. Nephrol. Dial. Transplant., 31 (3). S. 337 - 349. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2385

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Abstract

Recently, the European Medicines Agency approved the use of the vasopressin V2 receptor antagonist tolvaptan to slow the progression of cyst development and renal insufficiency of autosomal dominant polycystic kidney disease (ADPKD) in adult patients with chronic kidney disease stages 1-3 at initiation of treatment with evidence of rapidly progressing disease. In this paper, on behalf of the ERA-EDTA Working Groups of Inherited Kidney Disorders and European Renal Best Practice, we aim to provide guidance for making the decision as to which ADPKD patients to treat with tolvaptan. The present position statement includes a series of recommendations resulting in a hierarchical decision algorithm that encompasses a sequence of risk-factor assessments in a descending order of reliability. By examining the best-validated markers first, we aim to identify ADPKD patients who have documented rapid disease progression or are likely to have rapid disease progression. We believe that this procedure offers the best opportunity to select patients who are most likely to benefit from tolvaptan, thus improving the benefit-to-risk ratio and cost-effectiveness of this treatment. It is important to emphasize that the decision to initiate treatment requires the consideration of many factors besides eligibility, such as contraindications, potential adverse events, as well as patient motivation and lifestyle factors, and requires shared decision-making with the patient.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gansevoort, Ron T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arici, MustafaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benzing, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Birn, HenrikUNSPECIFIEDorcid.org/0000-0003-3715-7266UNSPECIFIED
Capasso, GiovambattistaUNSPECIFIEDorcid.org/0000-0003-3469-8614UNSPECIFIED
Covic, AdrianUNSPECIFIEDorcid.org/0000-0002-9985-2486UNSPECIFIED
Devuyst, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drechsler, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eckardt, Kai-UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emma, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knebelmann, BertrandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Meur, YannickUNSPECIFIEDorcid.org/0000-0001-8913-415XUNSPECIFIED
Massy, Ziad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Albert C. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortiz, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, FranzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torra, RoserUNSPECIFIEDorcid.org/0000-0001-8714-2332UNSPECIFIED
Vanholder, RaymondUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiecek, AndrzejUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zoccali, CarmineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Biesen, WimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-283983
DOI: 10.1093/ndt/gfv456
Journal or Publication Title: Nephrol. Dial. Transplant.
Volume: 31
Number: 3
Page Range: S. 337 - 349
Date: 2016
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2385
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GLOMERULAR-FILTRATION-RATE; REPLACEMENT THERAPY; VOLUME PROGRESSION; CLINICAL-TRIALS; CREATININE; OUTCOMES; PREDICTORS; ADPKD; CKDMultiple languages
Transplantation; Urology & NephrologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/28398

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